Browsing Science (Faculty of) by Title
Now showing items 2562-2581 of 3011
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Structural characterization and engineering of Adnectin inclusion bodies
(University of Waterloo, 2022-08-15)Protein aggregation is a fundamental process occurring as a response to aging, disease, protein overexpression and in many areas of biotechnology and medical applications. There has been much recent progress in determining ... -
Structural characterization of f-ALS associated SOD1 mutant aggregates using conformation-specific antibodies
(University of Waterloo, 2020-06-01)Superoxide dismutase 1 (SOD1) is a metalloenzyme ubiquitously expressed in all cells and acts as an antioxidant enzyme by catalyzing the dismutation of superoxide radicals. Several mutations in the gene encoding SOD1 are ... -
Structural Consequences of Calmodulin EF Hand Mutations
(American Chemical Society, 2017-02-21)Calmodulin (CaM) is a cytosolic Ca2+-binding protein that serves as a control element for many enzymes. It consists of two globular domains, each containing two EF hand pairs capable of binding Ca2+, joined by a flexible ... -
Structural Controls and Deformation History of the Orogenic Island Gold Deposit, Michipicoten Greenstone Belt, Ontario
(University of Waterloo, 2019-07-11)Island Gold is a currently producing mine on the high-grade orogenic Island Gold deposit in northern Ontario. It is located within the southern domain of the regional Goudreau Lake Deformation Zone (GLDZ), which trends ... -
Structural Geology and Geochronology of the Bernic Lake Area in the Bird River Greenstone Belt, Manitoba: Evidence for Syn-Deformational Emplacement of the Bernic Lake Pegmatite Group
(University of Waterloo, 2010-08-31)The Bernic Lake Formation in the Bird River greenstone belt consists dominantly of mafic to felsic arc volcanic and volcaniclastic rocks, with varying amounts of mafic to felsic intrusive rocks, including the Bernic Lake ... -
Structural geology and geochronology of the Kluane schist, southwestern Yukon Territory
(University of Waterloo, 2012-10-02)In light of the recent increase of mineral exploration in the northern Cordillera, private, educational, and governmental agencies have been compelled to revisit and research areas of the Cordillera whose geologic evolution ... -
The Structural Geology, Kinematics and Timing of Deformation at the Superior craton margin, Gull Rapids, Manitoba
(University of Waterloo, 2005)The Gull Rapids area, Manitoba, lies on the Superior craton margin and forms part of the Superior Boundary Zone (SBZ), a major collisional zone between the Archean Superior craton and the adjacent Paleoproterozoic Trans-Hudson ... -
Structural investigation of a new cadmium coordination compound prepared by sonochemical process: Crystal structure, Hirshfeld surface, thermal, TD-DFT and NBO analyses
(Elsevier, 2019-04)A new nanostructured cadmium complex containing a tridentate Schiff base ligand was sonochemically synthesized and characterized by XRPD, FT/IR, NMR, and single crystal X-ray crystallography. Structural data showed that ... -
Structural Investigation of Melatonin and its Metabolites as Possible Calmodulin Antagonists
(University of Waterloo, 2020-09-11)Calmodulin (CaM) is a small, highly conserved and ubiquitous calcium (Ca2+)-sensing protein that coordinates signal transduction through interactions with over 300 target molecules. It is composed of N- and C-terminal ... -
A structural investigation of novel fungal polyglycine hydrolases
(University of Waterloo, 2023-03-22)Polyglycine hydrolases (PGH) are a family of fungal proteases that are known to cleave the polyglycine linker of Zea mays chitinase, ChitA, thwarting one mechanism of plant defense against fungal infection. Previously, ... -
Structural Studies of a Complex Between Endothelial Nitric Oxide Synthase and Calmodulin at Physiological Calcium Concentration
(American Chemical Society, 2016-10-25)The small acidic protein calmodulin (CaM) serves as a Ca2+ sensor and control element for many enzymes including nitric oxide synthase (NOS) enzymes that play major roles in key physiological and pathological processes. ... -
A Structural Study of the Dogpaw Gold Deposit in the Rowan-Kakagi Greenstone Belt, Western Superior Province, Northwestern Ontario
(University of Waterloo, 2021-04-22)The Dogpaw deposit is a structurally controlled gold deposit hosted in the Neoarchean, Rowan-Kakagi greenstone belt of the Western Wabigoon of the Superior Province. The Rowan-Kakagi greenstone belt consists of two ... -
A structural-metamorphic approach to deciphering the exhumation of the Gubaoquan eclogite in the Beishan Orogenic Collage, NW China
(University of Waterloo, 2021-01-13)The Ordovician Gubaoquan eclogite is situated in the southern part of the Palaeozoic Beishan Orogenic Collage of the Central Asian Orogenic Belt in NW China. Mapping of an extensive section of the metamorphic tectonite ... -
Structure and Function in Early Glaucoma
(University of Waterloo, 2016-08-24)Glaucoma is a group of diseases, which exhibit a characteristic optic neuropathy and may result in progressive visual field loss. The most important risk factor is raised intraocular pressure (IOP) usually secondary to ... -
Structure and Function in Early Glaucoma
(University of Waterloo, 2017-01-23)Glaucoma is a general term that includes an array of ocular conditions that cause a specific neuropathy of the optic nerve (Greenfield, Bagga, et al. 2003) of which abnormalities associated with this disorder are localized ... -
The Structure and Function of Lung Surfactant: Effect of Amyloid Fibril Formation
(University of Waterloo, 2009-05-21)The alveoli of mammalian lungs are covered in a thin lipid film referred to as pulmonary surfactant. The primary purpose of pulmonary surfactant is to reduce the surface tension of the air/liquid interface allowing breathing ... -
The Structure and Internal Dynamics of Polypeptides Probed with Pyrene Excimer Fluorescence
(University of Waterloo, 2021-01-25)A combination of pyrene excimer fluorescence, fluorescence blob model (FBM), and molecular mechanics optimizations (MMOs) was applied to characterize a series of pyrene-labeled polypeptides. Analysis of the fluorescence ... -
The Structure and Properties of Weakly Bound Clusters
(University of Waterloo, 2020-10-07)In this thesis, two novel methods are introduced to advance the study of gas phase clusters. The structure similarity method is a computational technique that is able to quantify the structure difference for a pair of ... -
Structure and Property Correlations in Heavy Atom Radicals
(University of Waterloo, 2009-07-08)Neutral radicals represent versatile building blocks for the design of new conductive and magnetic molecular materials. In order to obtain good electron transport, materials displaying a high bandwidth W and a low on-site ... -
Structure and Thermodynamics of Drug-RNA Aptamer Interactions
(Bentham Science Publishers, 2013-03-01)This mini-review will provide an overview on the recent studies of structure and thermodynamics of RNA aptamers that target drug molecules. These aptamers are studied to provide insight into RNA drug interactions. This ...