Browsing Science (Faculty of) by Title
Now showing items 21-40 of 2965
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The action mechanism of daptomycin
(Elsevier, 2016-12-15)Daptomycin is a lipopeptide antibiotic produced by the soil bacterium Streptomyces roseosporus that is clinically used to treat severe infections with Gram-positive bacteria. In this review, we discuss the mode of action ... -
An Acyl-Linked Dimer of Daptomycin Is Strongly Inhibited by the Bacterial Cell Wall
(American Chemical Society, 2017-03-28)The lipopeptide antibiotic daptomycin is active against Gram-positive pathogens. It permeabilizes bacterial cell membranes, which involves the formation of membrane-associated oligomers. We here studied a dimer of daptomycin ... -
Adaptation to near addition lenses - Effect of AV/A ratio and age
(University of Waterloo, 2007-05-17)AIM: The primary purpose of this thesis was to evaluate the pattern of changes to accommodation and phoria when pre-presbyopic individuals perform near work for 20 minutes with +2D lenses. In addition, the thesis also ... -
The adaptive elements of disparity vergence: Dynamics and directional asymmetries.
(University of Waterloo, 2018-04-24)Vergence eye movements alter the angle between the two visual axes, creating changes in binocular fixation distance. They are primarily stimulated by retinal image disparities, but can also be driven by inputs from ocular ... -
Adhesion of Two Cylindrical Particles to a Soft Membrane Tube
(University of Waterloo, 2012-09-26)The interaction of nanoparticles with biological systems, especially interactions with cell membranes, has been a subject of active research due to its numerous applications in many areas of soft-matter and biological ... -
Adnectin Solubility and Dynamics
(University of Waterloo, 2019-10-28)Rapid growth of the global market for monoclonal antibodies (mAbs) has generated considerable interest in the development of alternative molecules that facilitate rapid discovery and manufacturing, while replicating the ... -
Adsorption and Desorption of DNA on Graphene Oxide Studied by Fluorescently Labeled Oligonucleotides
(American Chemical Society, 2011-03-15)Being the newest member of the carbon materials family, graphene possesses many unique physical properties resulting is a wide range of applications. Recently, it was discovered that graphene oxide can effectively adsorb ... -
Adsorption of DNA Oligonucleotides by Titanium Dioxide Nanoparticles
(American Chemical Society, 2014-01-28)Titanium dioxide (TiO2) or titania shows great promise in detoxification and drug delivery. To reach its full potential, it is important to interface TiO2 with biomolecules to harness their molecular recognition function. ... -
Adsorption of DNA onto gold nanoparticles and graphene oxide: surface science and applications
(Royal Society of Chemistry, 2012-06-28)The interaction between DNA and inorganic surfaces has attracted intense research interest, as a detailed understanding of adsorption and desorption is required for DNA microarray optimization, biosensor development, and ... -
Adsorption of Nanoceria by Phosphocholine Liposomes
(American Chemical Society, 2016-12-13)Nanoceria (CeO2 nanoparticle) possesses a number of enzyme-like activities. In particular, it scavenges reactive oxygen species based on in-vitro and in vivo antioxidation studies. An important aspect of fundamental physical ... -
Adsorption of surface-modified silica nanoparticles to the interface of melt poly (lactic acid) and supercritical carbon dioxide
(ACS Publications, 2015-04-28)With the purpose of fabricating polymer nanocomposite foams and preventing coalescence in foaming processes, the interfacial tension of poly (lactic acid) (PLA) -silica composites is investigated in this work. Synthesized ... -
Advanced Electrodes and Electrolytes For Long-Lived and High-Energy-Density Lithium-Sulfur Batteries
(University of Waterloo, 2017-05-16)The increasing demand on renewable but intermittent energy and the need for electrified transportation place great emphasis on energy storage. Lithium-sulfur (Li-S) batteries are promising systems due to the high theoretical ... -
Advanced research on Lithium-Sulfur battery : studies of lithium polysulfides.
(University of Waterloo, 2013-10-03)This thesis was devised as a fundamental study of the Li-S system by the use of 7Li Magic Angle Spinning (MAS) Nuclear Magnetic Resonance (NMR), X-ray Absorption Near- Edge Structure (XANES), and Non-Resonant Inelastic ... -
Advanced Separation Techniques in the Analysis of Environmental Pollutants
(University of Waterloo, 2012-04-30)Recent developments in chromatographic supports and instrumentation for liquid chromatography are enabling rapid and highly efficient separations. Various analytical strategies have been recently proposed, for example the ... -
Advances in Biamperometry with Applications in Ocular Toxicology
(University of Waterloo, 2013-10-02)This thesis presents advances in biamperometry, together with applications cyclic biamperometry, in in vitro ocular cytotoxicity assessment. For the cytotoxicity/viability assessment, cultured human corneal epithelial cells ... -
Advances in Multidimensional Chromatography
(University of Waterloo, 2012-07-23)Comprehensive two-dimensional gas chromatography (GC×GC) is among the most powerful methods used to separate complex samples. Two columns of different selectivities are coupled in series through a special interface ... -
Advances in Rock Core VOC Analyses for High Resolution Characterization of Chlorinated Solvent Contamination in a Dolostone Aquifer
(University of Waterloo, 2008-05-14)The current understanding of contaminant migration in fractured sedimentary rock aquifers is inadequate due to the difficulty in describing the geologic and hydrogeologic controls on contaminant fate and transport with ... -
Advances in solid-phase microextraction as sample preparation method for food analysis.
(University of Waterloo, 2015-02-25)Within all steps involved in the analytical process, sample preparation is considered the most time-consuming step. Therefore, substantial efforts have focused on the search for automated sample preparation strategies that ... -
Advances in Superconducting Circuit Quantum Electrodynamics
(University of Waterloo, 2022-01-31)The topics of this thesis are based on circuit quantum electrodynamics (cQED), a theoretical and experimental platform allowing the study of light--matter interaction. This platform is rich both in observable physical ... -
Advances in the density matrix renormalization group method for use in quantum chemistry
(University of Waterloo, 2008-05-01)Despite the success of modern quantum chemistry in predicting properties of organic molecules, the treatment of inorganic systems, which have many close lying states, remains out of quantitative reach for current methods. ...