Browsing Science (Faculty of) by Title
Now showing items 1443-1462 of 2879
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The Investigation of Tear Film Osmolality as a Clinical Instrument Used in Assessments of the Tear Film and Dry Eye Disease
(University of Waterloo, 2010-01-11)Introduction: Tear film osmolality is a product of the varying concentrations of dissolved solutes (proteins, lipids and mucins) in the tear fluid. Research suggests that a hyperosmotic tear film is a trait common to ... -
Investigation of the effect mutations of CaM have upon in vitro and ex vivo function
(University of Waterloo, 2010-01-22)Calmodulin (CaM) is a calcium-binding protein that has promiscuous regulatory interactions with over three hundred intracellular protein targets. The focus of this study was to characterize the functional role of phosphorylated ... -
Investigation of the Efficacy of in situ Degradation Methods for Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonic Acid (PFOS) in Groundwater
(University of Waterloo, 2018-01-17)Per- and polyfluoroalkyl substances (PFASs) are a group of emerging contaminants that include perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS). PFASs can be released into groundwater through the ... -
Investigation of the Microbial Glyoxalase System
(University of Waterloo, 2011-05-19)The Glyoxalase system is composed of two metalloenzymes, Glyoxalase I and Glyoxalase II, that catalyze the conversion of toxic, metabolically produced alpha-ketoaldehydes, such as methyglyoxal, in the presence of a thiol ... -
Investigation of the Optical Properties of Nanostructured Transparent Conducting Oxides
(University of Waterloo, 2013-04-30)Transparent conducting oxides (TCOs) usually have high conductivity and transparency in the visible range and have been widely used in daily life. Recently, TCOs have attracted great interest due to their potential ... -
Investigation of the Presence of a G-quadruplex In the Hoechst Dye Binding DNA Aptamer
(University of Waterloo, 2022-04-22)Aptamers are nucleic acid sequences that have been selected to bind to a ligand with high affinity and selectivity. Aptamers have great potential for use in various biotechnological and medical applications but understanding ... -
Investigation of the role of Hindsight in the development of the Drosophila midgut
(University of Waterloo, 2014-02-21)The Drosophila adult midgut is maintained through the division and differentiation of a population of intestinal stem cells (ISCs) (Issigonis and Matunis, 2010). The epithelial cells of the adult midgut are derived from ... -
Investigation of Thermoelectric Thallium Chalcogenides
(University of Waterloo, 2020-01-24)Thermoelectric materials have drawn extensive attention because of their potential to provide assistance in reducing the usage of fossil fuel sources and the greenhouse effect. Throughout this thesis, the purpose was to ... -
Investigation of vision strategies used in a dynamic visual acuity task
(University of Waterloo, 2017-10-24)Purpose: Dynamic visual acuity (DVA), the ability to resolve fine details of a moving target, requires spatial resolution and accurate oculomotor control. Individuals who engage in activities in highly dynamic visual ... -
Investigation of β-xylosidase, α-L-arabinofuranosidase and acetylesterase from Thermotoga hypogea
(University of Waterloo, 2008-09-03)Hemicellulases are key components in the degradation of plant biomass and carbon flow in nature. Thermotoga hypogea is a bacterium that can grow anaerobically at 90°C. It utilizes carbohydrates and peptides as energy and ... -
Investigations into Cellulolysis in Carbon Amended Tailings
(University of Waterloo, 2011-05-24)Modified cellulase enzyme assay methods were developed to determine the potential of using enzyme activities to evaluate the decomposition of organic matter in carbon amended mine tailings systems. Cellulase assays are ... -
Investigations into food web structure in the Beaufort Sea
(University of Waterloo, 2017-12-18)The effects of climate change on marine ecosystems are most pronounced in the Arctic, where ice free summers have been predicted to occur by mid-century. Climate-related changes to sea ice phenology, oceanographic habitat ... -
Investigations into Intracellular Thiols of Biological Importance
(University of Waterloo, 2007-02-01)The presence of thiols in living systems is critical for the maintenance of cellular redox homeostasis, the maintenance of protein thiol-disulfide ratios and the protection of cells from reactive oxygen species. In addition ... -
Investigations into Streptomyces azureus Thiostrepton-resistance rRNA Methyltransferase and its Cognate Antibiotic
(University of Waterloo, 2008-12-16)Thiostrepton (TS: TS; C72H85N19O18S5) is a thiazoline antibiotic that is effective against Gram-positive bacteria and the malarial parasite, Plasmodium falciparum. Tight binding of TS to the bacterial L11-23S ribosomal RNA ... -
Investigations into the toxicity and toxicokinetics of individual and binary mixtures of CCME petroleum hydrocarbon distillates in soil
(University of Waterloo, 2012-05-18)The Canada-wide Standards for Petroleum Hydrocarbons (PHC CWS) in soils are remedial standards based on four petroleum distillates (Fraction 1 [F1; ECN C6-C10], Fraction 2 [F2; ECN >C10-C16], Fraction 3 [F3; ECN >C16-C34], ... -
Investigations of Bacterial Methionine Aminopeptidase
(University of Waterloo, 2009-10-05)The pathway representing methionine integration and excision is an increasingly important target in drug design. Methionine aminopeptidase (MetAP), a metalloprotease responsible for cleaving the N-terminal methionine from ... -
Investigations of InAsP/InP Semiconductor Devices for Quantum Communication Technologies
(University of Waterloo, 2015-01-19)This thesis presents a set of magnetotransport experiments which explore the advantages of InAsP/InP quantum well material and quantum dot structures for spin/photon devices, with a view towards quantum communication. The ... -
Investigations of Magnetic Model Systems Using Coupled Cluster Based Approaches
(University of Waterloo, 2017-08-23)Over the past decades, the quantum mechanical description of magnetic phenomena has been well developed. However, the first principle calculations of the physical properties of magnetic systems is still a challenge. One ... -
Investigations of the Natural Product Antibiotic Thiostrepton from Streptomyces azureus and Associated Mechanisms of Resistance
(University of Waterloo, 2013-03-11)The persistence and propagation of bacterial antibiotic resistance presents significant challenges to the treatment of drug resistant bacteria with current antimicrobial chemotherapies, while a dearth in replacements for ... -
Investigations on the action mode of Bacillus thuringiensis Cyt2Aa1 toxin
(University of Waterloo, 2015-08-11)B. thuringiensis is a Gram-positive bacterium that, while quite otherwise closely related to the soil saprophyte Bacillus cereus, is unique in producing a large variety of membrane-damaging, insecticidal protein toxins. ...