Browsing Engineering (Faculty of) by Subject "drug delivery"
Now showing items 1-12 of 12
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Cationic Lytic Peptides as Drugs or Drug Carriers for Targeted Cancer Therapy
(University of Waterloo, 2015-01-05)Cationic lytic peptides (CLPs) have emerged as new anticancer agents with a new mode of action. This category of peptides is given the characteristics of overall positive charges and amphiphilicity, inducing cell death by ... -
Curdlan 1,3-Beta-Glucans: A New Platform for Polymer Drug Delivery
(University of Waterloo, 2011-04-25)1,3-β-glucans are a class of natural polysaccharides with unique pharmacological properties and the ability to form triple helical structures and resilient gels. Curdlan and other 1,3-β-glucans have found application ... -
Development of Microparticles Created from Physically Modified Starch Granules for the Uptake and Release of Drugs
(University of Waterloo, 2021-01-07)Controlled release drug delivery systems are, depending on the desired effect, generally an improvement over conventional drug delivery. Through material design, drugs can be delivered with temporal and spatial control, ... -
Double Emulsion Mucoadhesive Nanoparticles for Hydrophilic Ocular Drug Delivery
(University of Waterloo, 2018-09-05)Common eye diseases such as conjunctivitis affect around 6 million people annually. Although eye drops are the most common treatment for these diseases, topical administration is limited by low ocular bioavailability due ... -
Evaluation of endothelial cell response to drug for intraocular lens delivery
(University of Waterloo, 2011-10-27)Cataract is one of the leading causes of vision loss worldwide. The rate of cataract surgery has been steadily increasing. Toxic Anterior Segment Syndrome (TASS) is a sterile inflammatory response in the anterior segment ... -
Image-based spatio-temporal model of drug delivery in a heterogeneous vasculature of a solid tumor — Computational approach
(Elsevier, 2019-05)The solute transport distribution in a tumor is an important criterion in the evaluation of the cancer treatment efficacy. The fraction of killed cells after each treatment can quantify the therapeutic effect and plays as ... -
Modeling and Control of a Magnetic Drug Delivery System
(University of Waterloo, 2012-08-29)Therapeutic operation risk has been reduced by the use of micro-robots, allowing highly invasive surgery to be replaced by low invasive surgery (LIS), which provides an effective tool even in previously inaccessible parts ... -
Mucoadhesive Nanoparticles for Treatment of Influenza A
(University of Waterloo, 2017-08-31)Influenza A is the most pandemic-prone class of the influenza virus, with new strains emerging every year. Though vaccination is promoted as the vanguard against wide-spread infection, it is not enough to withstand mutating ... -
Multifunctional Nano MOF Particle for Anticancer Drug Delivery
(University of Waterloo, 2022-01-05)PCN-224 MOF nano particles were modified with a peptide named NPKMTX to deliver dox to cancer cells. -
PSEUDO-TERNARY PHASE DIAGRAMS OF A DRUG DELIVERY SYSTEM
(University of Waterloo, 2009-05-04)The purpose of this research was to develop the pseudo-ternary phase diagrams for a model drug delivery system consisting of vitamin E (model drug) + soybean oil + surfactant + co-surfactant (anhydrous glycerol) + water. ... -
Synthesis and Solution Properties of Water-soluble Fullerene Polymeric Systems
(University of Waterloo, 2011-09-20)Water-soluble fullerene containing polymers comprising of poly(2-(dimethylamino) ethyl methacrylate)-fullerene (PDMAEMA-C60) with targeting moieties, poly(oligo(ethylene glycol) methyl ether methacrylate)-C60 (POEGMA-C60), ... -
Towards principled design of cancer nanomedicine to accelerate clinical translation
(Elsevier, 2022-01)Nanotechnology in medical applications, especially in oncology as drug delivery systems, has recently shown promising results. However, although these advances have been promising in the pre-clinical stages, the clinical ...