Browsing Health (Faculty of) by Supervisor "Tupling, A. Russell"
Now showing items 1-10 of 10
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Characterizing the Role of Phospholamban in Duchenne Muscular Dystrophy
(University of Waterloo, 2018-01-16)Duchenne muscular dystrophy (DMD) and the murine model, mdx, are recessive X-linked myopathies characterized by aberrant Ca2+-handling resulting in muscle atrophy and weakness. Phospholamban (PLN) is a protein inhibitor ... -
Deletion of Sarco(endo)plasmic Reticulum Ca2+-ATPase Regulatory Proteins: Impacts on Energy Metabolism and Obesity
(University of Waterloo, 2017-11-28)The sarco(endo)plasmic reticulum (SR) Ca2+-ATPase (SERCA) is responsible for maintaining low cytosolic [Ca2+] through the ATP-dependent pumping of Ca2+ ions from the cytosol into the SR lumen. SERCA activity has the ... -
Does Sarcolipin Ablation Alter Deflazacort Treatment Effects in mdx Mice?
(University of Waterloo, 2017-09-27)Duchenne Muscular Dystrophy (DMD) and the murine model mdx are degenerative diseases that are characterized by the absence of the protein dystrophin causing membrane instability, calcium (Ca2+) influx, and progressive ... -
Effects of 4-hydroxy-2-nonenal on SERCA pump structure and function in skeletal and cardiac muscle
(University of Waterloo, 2015-11-30)The sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) pumps are approximately 100 kDa transmembranous proteins that catalyze the ATP-dependent transport of cytosolic Ca2+ [Ca2+]i into the sarcoplasmic reticulum (SR), thereby ... -
The Effects of a Calcineurin Inhibitor on Muscle Fibre Type and the Pathology of Centronuclear Myopathy in PlnOE Mice
(University of Waterloo, 2017-01-27)The sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) pump is responsible for pumping calcium from the cytosol back into the lumen of the sarcoplasmic reticulum post contraction. SERCA activity can be reduced by an inhibitory ... -
Examining the Effect of Parvalbumin Overexpression on the Development of Centronuclear Myopathy in Phospholamban Overexpressing Mice
(University of Waterloo, 2022-05-18)Within the myofibre, the sarco(endo)plasmic reticulum (SR) Ca2+ ATPase (SERCA) has an essential role in regulating intracellular Ca2+ concentrations ([Ca2+]i) by pumping Ca2+ into the SR. There are several known regulators ... -
Examining the Effects of Exogenous Ketones on Exercise Metabolism and Performance in Male Varsity Athletes
(University of Waterloo, 2018-05-24)Previous research has shown that administration of exogenous acetoacetate (AcAc), beta-hydroxybutyrate (BHB) and glucose in a perfused rodent heart model can increase cardiac output while reducing oxygen uptake compared ... -
NADPH Oxidase-dependent ROS Production and Impaired Ca2+ Regulation are Associated with Exercise-induced Cardiac Fatigue in the Rat
(University of Waterloo, 2015-12-10)Cardiac fatigue is a phenomenon that is characterized by a transient reduction in left ventricular contractile and/or relaxation function following acute aerobic exercise. Few studies have utilized rodent models to examine ... -
Protection against high fat diet induced obesity in mdx mice: is sarcolipin involved?
(University of Waterloo, 2018-02-15)Sarcolipin (SLN) is a 31 amino acid proteolipid and one of the regulators of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) pumps. Previous research has shown that sarcolipin levels in muscles from wild type (WT) mice ... -
THE ROLE OF CYTOSOLIC CALCIUM IN POTENTIATION OF MOUSE LUMBRICAL MUSCLE
(University of Waterloo, 2014-04-09)Following contractile activity, fast twitch skeletal muscle exhibits increases in submaximal force known as potentiation. Although there is no consensus on the purpose of potentiation, it is known to enhance power during ...