Browsing Health (Faculty of) by Supervisor "Mielke, John"
Now showing items 1-10 of 10
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Applying the Allostatic Load Model to Investigate the Biological Embedding of Psychosocial Stress in Firefighters
(University of Waterloo, 2022-08-30)Overview Psychosocial factors are recognised as a significant source of stress in the workplace, and long-term exposure to such stressors may increase chronic disease risk through physiological wear and tear quantified ... -
Are There Sex-Linked Differences Across the Longitudinal Axis of the Rat Hippocampus Following Ischemic Injury?
(University of Waterloo, 2016-10-14)Ischemic strokes occur when an occluded blood vessel limits the delivery of oxygen and nutrients to neurons, and can result in widespread cell death. Although stroke is the third leading cause of death and a major cause ... -
Developing a More Culturally Appropriate Approach to Surveying Adverse Childhood Experiences Among Indigenous Peoples in Canada
(University of Waterloo, 2019-02-22)Introduction: Adverse childhood experiences (ACE) are (in a dose-dependent manner) associated with both health-risk behaviours and the development of chronic disease, and thus pose a significant threat to health and ... -
Do primary and secondary psychosocial stressors vary in their effect upon plasticity-related proteins?
(University of Waterloo, 2022-09-01)The generous distribution of glucocorticoid receptors (GRs) is a primary reason for the widespread effects of stress on all biological systems. The prefrontal cortex (PFC), which is crucial in executive functioning, ... -
Does a sex difference of AMPA receptor trafficking after oxygen-glucose deprivation exist in rat cortical and hippocampal slices?
(University of Waterloo, 2019-09-17)Stroke, which is caused by an interruption of blood supply to the brain, is a major public health burden because it is one of the leading global causes of death and disability. AMPA receptor trafficking is considered to ... -
The Effects of Chronic Early-life Social Isolation on Hippocampal Cell Number and Hippocampal-Dependent Learning and Memory in Male and Female Rats
(University of Waterloo, 2019-04-30)Before, and for a considerable time after birth, the brain is especially plastic and vulnerable to influences from the environment. Exposure to stressful, or adverse, early-life social experiences, such as social isolation, ... -
Examination of mechanisms underlying the effect of single-session exercise on cortical plasticity
(University of Waterloo, 2018-10-10)Individuals who routinely participate in physical activity are the beneficiaries of a wide array of health benefits. As well, recent observations in humans have identified that even a single session of aerobic exercise can ... -
Improving Spaces for Women First Responders: Investigating women’s occupational experiences using a comparative grounded theory
(University of Waterloo, 2022-08-10)Background: First response work has historically been designed for and performed by men; yet more women than ever are conducting this work. Research suggests women first responders face unequal access to resources and ... -
Patients’ Accounts of Non-Acceptance and Non-Adherence to Drug Treatment in Depression A Scoping Review and Narrative Synthesis of Research Findings on Patients’ Views on Antidepressants
(University of Waterloo, 2017-06-19)Major depressive disorder (MDD) is a disabling condition with a high frequency of recurrence and non-recovery, resulting in serious morbidity and mortality (Kessler & Bromet, 2013; Stotland, 2012; Alonso et al., 2013). ... -
Work-related psychosocial stress and allostatic load within firefighters
(University of Waterloo, 2018-01-10)The aim of this study was to investigate the nature and type of psychosocial stress experienced by firefighters through investigating the cumulative effects of work-related factors on their health by reviewing current ...