Browsing Health (Faculty of) by Supervisor "Duncan, Robin"
Now showing items 1-8 of 8
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Characterization of a novel truncated isoform of murine AGPAT4 arising from predicted splice variants
(University of Waterloo, 2021-06-02)The acylglycerophosphate acyltransferase (AGPAT)/lysophosphatidic acid acyltransferase (LPAAT) family of enzymes is responsible for the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA), a precursor of ... -
Characterization of Changes in the Kidney, Liver, and Adipose Tissue of RTSAKO Mice
(University of Waterloo, 2018-11-02)Our laboratory has developed a novel genetic mouse model with kidney-specific lipid accumulation called RTSAKOs. The principle aim of my thesis was to study differences in the expression of genes and proteins related to ... -
Characterization of the critical biochemical and physiological role of 1-acylglycerol-3-phosphate-O-acyltransferase 4 (AGPAT4) in white adipose tissue
(University of Waterloo, 2016-08-18)White adipose tissue (WAT) is an endocrine and lipid storage organ that is imperative to mammals for the maintenance of energy homeostasis. WAT depot size and triacylglycerol (TAG) content is determined by the regulation ... -
Characterization of the effect of the menstrual cycle, estradiol and Fads2 transcript variants on fatty acid composition and enzyme expression
(University of Waterloo, 2016-08-29)Estrogen is believed to regulate fatty acid composition based on observations of differences between men and women, and changes associated with altered estrogen levels in women during pregnancy, menopause and hormone ... -
Identification and characterization of a novel microsomal enzyme involved in cardiolipin synthesis and remodeling
(University of Waterloo, 2018-05-17)Cardiolipin (CL) is a specialized dimeric phospholipid predominantly found in the inner mitochondrial membrane in eukaryotes. Following de novo synthesis, the acyl chains of CL are remodeled in a manner that is tissue- and ... -
Investigation of a potential therapeutic role for N-oleoylethanolamide and N-linoleoylethanolamide using lymphoblasts deficient in Tafazzin
(University of Waterloo, 2020-09-01)Barth syndrome (BTHS) is a rare X-linked genetic disorder caused by mutations in the TAZ gene that encodes for a cardiolipin (CL) remodelling enzyme, Tafazzin. Due to an inability to remodel the fatty acyl chains on CL ... -
Phenotypic Characterization of the Male Tafazzin-Knockout Mouse Model of Barth Syndrome at 3-, 6-, and 12-Months of Age
(University of Waterloo, 2022-05-18)Barth Syndrome (BTHS) is a devastating disorder caused by mutations in the gene encoding for Tafazzin (TAZ), a key enzyme involved in the biosynthesis of the phospholipid cardiolipin, which is vital for maintaining the ... -
Studies on the Physiology and Glucose Metabolism of 14-16-Month-Old Female RTSAKO Mice
(University of Waterloo, 2020-09-01)Obesity is a global epidemic. Characterized by an imbalance between energy intake and expenditure, the metabolic and physiological dysfunctions that it yields can result in other diseases such as diabetes. Although several ...