Browsing Health (Faculty of) by Title
Now showing items 123-142 of 1102
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Characterization of Changes in the Kidney, Liver, and Adipose Tissue of RTSAKO Mice
(University of Waterloo, 2018-11-02)Our laboratory has developed a novel genetic mouse model with kidney-specific lipid accumulation called RTSAKOs. The principle aim of my thesis was to study differences in the expression of genes and proteins related to ... -
Characterization of murine HRASLS-1: transcript variant analysis, metabolic regulation, developmental expression, and a role in inflammation
(University of Waterloo, 2014-08-27)N-acylethanolamides (NAE) are involved in a variety of biological processes ranging from fat oxidation to inflammation mediation. Recently, the HRASLS family, a group of class II tumour suppressor proteins, have been ... -
Characterization of the critical biochemical and physiological role of 1-acylglycerol-3-phosphate-O-acyltransferase 4 (AGPAT4) in white adipose tissue
(University of Waterloo, 2016-08-18)White adipose tissue (WAT) is an endocrine and lipid storage organ that is imperative to mammals for the maintenance of energy homeostasis. WAT depot size and triacylglycerol (TAG) content is determined by the regulation ... -
Characterization of the effect of the menstrual cycle, estradiol and Fads2 transcript variants on fatty acid composition and enzyme expression
(University of Waterloo, 2016-08-29)Estrogen is believed to regulate fatty acid composition based on observations of differences between men and women, and changes associated with altered estrogen levels in women during pregnancy, menopause and hormone ... -
Characterization of the effects of sex, pregnancy, and 17β-estradiol on docosahexaenoic acid biosynthesis
(University of Waterloo, 2013-09-27)Docosahexaenoic acid (DHA) is an omega-3 polyunsaturated fatty acid (n-3 PUFA) required for fetal neurodevelopment. Increased DHA levels are associated with 17β-estradiol levels, as DHA is higher in women relative to men ... -
Characterization of the Human Plasma Macrolipidome using Standard Reference Material 1950 - Metabolites in frozen human plasma
(University of Waterloo, 2022-01-26)Standard Reference Material (SRM) 1950 Metabolites in frozen human plasma is a pooled plasma sample created by the National Institute of Standards and Technology (NIST) to be representative of plasma from the population ... -
Characterizing a Novel Enzyme Involved in Cardiolipin Remodelling
(University of Waterloo, 2023-12-05)Background: Cardiolipin (CL) is a specialized dimeric phospholipid comprising approximately 25% of total phospholipids in the inner mitochondrial membrane in eukaryotes, where it functions in energy metabolism, autophagy ... -
Characterizing poly-substance use and its associations with anxiety and depression among a sample of Canadian high school students
(University of Waterloo, 2022-01-05)In any given year, one in five Canadians experience mental illness. The majority of mental illnesses originate in adolescence or young adulthood. Many complex factors can contribute to this, including substance use. However, ... -
Characterizing Sex Differences in Lipid Metabolism during an Acute, 30-Minute Bout of Moderate- Intensity Continuous (MIC) Exercise
(University of Waterloo, 2021-01-05)INTRODUCTION: Increased intramyocellular lipid (IMCL) size and storage in the subsarcolemmal region of the myocyte are associated with insulin resistance (IR) and the development of type 2 diabetes (T2D). Women have a ... -
Characterizing Sex Differences in Skeletal Muscle Anaerobic Metabolism during an Acute Bout of High Intensity Interval Exercise
(University of Waterloo, 2020-09-03)INTRODUCTION: Exercise is known to improve insulin sensitivity (IS); however, its effectiveness may be absent or blunted in women, particularly following high intensity interval (HII) training. Sex differences in anaerobic ... -
Characterizing site-specific body composition of older adults and their associations with strength, functional capacity, and metabolic health
(University of Waterloo, 2021-06-03)Background: Ageing is associated with skeletal muscle atrophy and increased intramuscular adipose tissue. Emerging evidence indicates that specific muscle groups may be largely responsible for the ageing-related degradation ... -
Characterizing the Biomechanical Exposures Associated with Common and High Demand Personal Support Worker Tasks
(University of Waterloo, 2023-08-31)Background: The physical demands that personal support workers (PSWs) are exposed to are increasing as our population ages and our society is increasingly shifting to at-home care, resulting in increases in workload ... -
Characterizing the dynamics of vestibular reflex gain modulation using balance-relevant sensory conflict
(University of Waterloo, 2023-09-21)Electrical vestibular stimulation (EVS) can be used to evoke reflexive body sways as a probe of vestibular control of balance. However, EVS introduces sensory conflict by decoupling vestibular input from actual body motion, ... -
Characterizing the Role of Phospholamban in Duchenne Muscular Dystrophy
(University of Waterloo, 2018-01-16)Duchenne muscular dystrophy (DMD) and the murine model, mdx, are recessive X-linked myopathies characterized by aberrant Ca2+-handling resulting in muscle atrophy and weakness. Phospholamban (PLN) is a protein inhibitor ... -
Characterizing the Roles of Myoregulin and Dwarf Open Reading Frame in Regulating Calcium Homeostasis in Muscle
(University of Waterloo, 2024-01-26)The sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs) are responsible for inducing muscle relaxation and are integral to the maintenance of intracellular calcium (Ca2+) homeostasis. As such, their activity is modulated ... -
Characterizing the Variability of Kinematic Outcome Measures and Compensatory Movements using Inertial Measurement Units
(University of Waterloo, 2019-01-22)Cost-effective wearable sensors to measure movement have gained traction as research and clinical tools. The potential to quantify movement with a portable and inexpensive way could provide benefits to patient populations ... -
Choir Participation and Community Wellbeing: A Social Identity Approach
(University of Waterloo, 2019-09-03)Research about choir and community wellbeing shows that there is a positive association between the two constructs. In addition, the positive association between choir participation and community wellbeing seems to be ... -
Choosing Healthcare Options by Involving Canada's Elderly: a protocol for the CHOICE realist synthesis project on engaging older persons in healthcare decision-making
(British Medical Association Journal, 2015-11-01)Introduction: While patient and citizen engagement has been recognised as a crucial element in healthcare reform, limited attention has been paid to how best to engage seniors-the fastest growing segment of the population ... -
Clinical assessment of body composition after spinal cord injury. An observational study.
(University of Waterloo, 2009-11-19)Background: Persons who sustain a spinal cord injury (SCI) experience a dramatic loss of muscle and bone, and a dramatic increase in adipose tissue. It has been suggested that the muscle atrophy, obesity, and sublesional ... -
Clinical pharmacists and nurses' perceptions on implementing anticoagulation therapy recommendations for the frail elderly: An exploratory study based on psychological theory
(University of Waterloo, 2017-05-15)Background: Stroke is a leading cause of mortality and disability in Canada. Persons with atrial fibrillation (AF) have a five-fold increased risk of developing a stroke. AF is a significant contributor to stroke at all ...