Browsing Theses by Subject "skeletal muscle"
Now showing items 1-8 of 8
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Apoptotic signalling and structural alterations in autophagy-deficient murine skeletal muscle
(University of Waterloo, 2014-10-15)Autophagy is a catabolic process by which the cell targets and degrades cytoplasmic materials, such as proteins and organelles. Autophagy is required for the control of muscle mass under catabolic conditions, but is also ... -
Autophagy Regulates the NOTCH Signaling Pathway During Skeletal Muscle Cell Differentiation
(University of Waterloo, 2021-06-01)Research has indicated a crucial role for autophagy during skeletal muscle differentiation. More so, the inhibition of autophagy using 3MA (3-methyladenine), CQ (chloroquine), and shRNA against Atg7 has been shown to impair ... -
Does Sarcolipin Ablation Alter Deflazacort Treatment Effects in mdx Mice?
(University of Waterloo, 2017-09-27)Duchenne Muscular Dystrophy (DMD) and the murine model mdx are degenerative diseases that are characterized by the absence of the protein dystrophin causing membrane instability, calcium (Ca2+) influx, and progressive ... -
The Effect of Mitochondrial Biogenesis on Apoptotic Susceptibility in L6 Myoblasts
(University of Waterloo, 2010-09-27)Mitochondria play an essential role in cell metabolism as well as apoptotic signaling. Chronic endurance exercise has been shown to increase mitochondrial content in skeletal muscle. Interestingly, endurance exercise has ... -
Effects of high-fat feeding on skeletal muscle insulin signalling in sarcolipin knockout mice
(University of Waterloo, 2010-08-26)Type II diabetes mellitus (T2DM) has been associated with the onset of diet-induced obesity, which is currently on the rise worldwide. T2DM is typically characterized by insulin resistance in peripheral tissues such as ... -
Examining the role of autophagy in modulating apoptotic signaling and skeletal muscle recovery after cardiotoxin injury in tamoxifen-inducible, skeletal muscle-specific Atg7 knockdown mice
(University of Waterloo, 2015-10-06)Skeletal muscle is a unique tissue composed of multinucleated, post-mitotic fibers. Despite its post-mitotic nature, skeletal muscle has an astounding ability to regenerate after injury largely thanks to muscle-specific ... -
Muscle Quantity and Quality after Chronic Spinal Cord Injury: An investigation of calfmuscle cross-sectional area and density after long-term paralysis
(University of Waterloo, 2014-05-22)Background/Objectives: Individuals with a spinal cord injury (SCI) experience reductions in lower-extremity muscle mass and increased fatty-infiltration of skeletal muscle, predisposing them to an increased risk of specific ... -
The role of glutathione depletion in skeletal muscle apoptotic signalling in young and old rats
(University of Waterloo, 2010-09-27)There is substantial evidence that oxidative stress causes negative outcomes in many cell and tissue types. This is especially true of skeletal muscle, as it is continually subjected to various sources of reactive oxygen ...