Browsing Theses by Subject "Skeletal Muscle"
Now showing items 1-5 of 5
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Effects of Sarcolipin Ablation on Mitochondrial Enzyme Adaptations to Exercise Training
(University of Waterloo, 2013-01-25)Changes in intracellular Ca2+ ([Ca2+]f) and high-energy phosphates are known to induce adaptive changes in skeletal muscle during endurance exercising training, including mitochondrial biogenesis. Levels of [Ca2+]f are ... -
Examination of Voluntary Wheel Running and Skeletal Muscle Metabolism in the Sarcolipin Knock-Out Mouse
(University of Waterloo, 2012-01-19)Sarcolipin (SLN) is a small sarcoplasmic reticulum (SR) integral membrane protein that regulates the SR Ca2+-ATPase (SERCA). Previous studies indicate that the functional interaction between SLN and SERCA is thermogenic ... -
Morphological and Apoptotic Alterations in Skeletal Muscle of Mice Deficient in Apoptosis Repressor with Caspase Recruitment Domain
(University of Waterloo, 2012-01-05)Altered apoptotic signaling in skeletal muscle has been observed in a number of disease states associated with skeletal muscle atrophy. Therefore, understanding the mechanisms that lead to increased skeletal muscle apoptosis ... -
The Role of Apoptosis Repressor with Caspase Recruitment Domain in Aging Mouse Skeletal Muscle Morphology and Apoptotic Signaling
(University of Waterloo, 2015-01-23)Abstract Aging is associated with a loss of skeletal muscle mass, known as sarcopenia, which results in numerous degenerative alterations and decreased strength. One of the major mechanisms influencing muscle wasting in ... -
The Role of Sarcolipin in Calcium Handling and Obesity
(University of Waterloo, 2010-05-19)Sarcolipin (SLN), a small molecular weight, hydrophobic protein found in skeletal muscle, is a known regulator of sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) pumps. Earlier in vitro reconstitution experiments have ...