Browsing Theses by Supervisor "Wettig, Shawn"
Now showing items 1-8 of 8
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Cationic Gelatin/Pluronic-based Nanoparticles as Novel Non-Viral Delivery Systems for Gene Therapy
(University of Waterloo, 2018-08-09)A delivery system is essential to protect the DNA from degradation because of the extracellular and intracellular barriers. Two main types of delivery systems have been used to deliver genes into the body: viral and non-viral ... -
Development of a Novel, Microemulsion System for the Simultaneous Delivery of Hydrophilic and Hydrophobic Active Pharmaceutical Ingredients (APIs)
(University of Waterloo, 2020-09-28)Concurrent chronic disease and ensuing multi-morbidity are a debilitating reality for millions of Canadians. This adversity is compounded by increased pill burden and decreased patient adherence. Microemulsions (MEs) serve ... -
The Effect of a Source Change for an Active Pharmaceutical Ingredient (API) or Excipient on the Finished Drug Product
(University of Waterloo, 2016-08-10)The global cost of health care is increasing year after year, and one of the ways governments and health care providers are looking to reduce cost is by reducing the cost of drug products. The generic industry is under ... -
In-solution and physical state properties of polymer and lipid excipients and their effects on the supersaturation evolution of poorly water-soluble drugs
(University of Waterloo, 2023-04-14)Solubility has become an increasing issue for the pharmaceutical industry, as the advances in combinatorial chemistry and high throughput screening methods have resulted in an increase in the molecular weight and lipophilicity ... -
Mixed Micelle Characterization of Pluronic and Gemini Surfactant – Based Gene Therapy Carriers and a Connection to Transfection Efficiency
(University of Waterloo, 2020-09-16)Non-viral gene therapy formulation development often relies on a rational design approach, where vector components are selected based on individual characteristics known to favour transfection efficiency. However, these ... -
Nanoscale physics of surfactant gene delivery
(University of Waterloo, 2016-01-18)Medicine has met a revolution in the expansion of possibilities for therapy based upon synthetic gene delivery. Imagine the ability to correct problems of a genetic origin with a simple drug -- such science fiction fantasies ... -
Synthesis and Characterisation of Chiral Nanomaterials and their Influence on Stem Cell Differentiation
(University of Waterloo, 2017-08-11)Tissue engineering is a field related to regenerative medicine which aims at replacing or regenerating a patient’s tissue, usually using a combination of cells and a bioactive material which is designed to influence cell ... -
Synthesis and Characterization of Dissymmetric Gemini Surfactants for Gene Delivery Application
(University of Waterloo, 2016-08-29)The lack of safe and efficient gene- delivery methods has been constantly a limiting obstacle to human gene therapy. Viral vectors have been superior in delivering exogenous DNA or RNA into a foreign cell due to their ...