Browsing Theses by Supervisor "Guillemette, Guy"
Now showing items 1-3 of 3
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Biophysical Investigations of the Interactions between Calmodulin and Nitric Oxide Synthase Enzymes
(University of Waterloo, 2017-12-15)Nitric Oxide (•NO) is an essential biomolecule that has physiological functions in neurotransmission, vasodilation and immune response. •NO is produced by a family of enzymes known as nitric oxide synthases (NOS). NOS ... -
In vitro studies of NOS inhibitors using purified human NOS isozymes
(University of Waterloo, 2017-12-18)Endogenous nitric oxide (NO) is derived from L-arginine via a chemical reaction catalyzed by nitric oxide synthases (NOS). Three NOS isozymes are found in humans: neuronal NOS (nNOS), endothelial NOS (eNOS) and inducible ... -
Structural Investigation of Melatonin and its Metabolites as Possible Calmodulin Antagonists
(University of Waterloo, 2020-09-11)Calmodulin (CaM) is a small, highly conserved and ubiquitous calcium (Ca2+)-sensing protein that coordinates signal transduction through interactions with over 300 target molecules. It is composed of N- and C-terminal ...