Browsing Theses by Supervisor "Gorbet, Maud"
Now showing items 1-6 of 6
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Development of an In-Vitro Model to Study the Effect of Shear and Biomaterial on Neutrophil Extracellular Trap Release by Blood Neutrophils and HL-60 Cells
(University of Waterloo, 2023-07-10)Cardiovascular biomaterials are essential for the support of damaged or diseased cardiovascular tissue and structures. Their applications include stents, heart valves, vascular grafts, and pacemakers. The success of these ... -
Development of In Vitro Biocompatibility Models of the Ocular Surface
(University of Waterloo, 2020-09-30)Over 120 million individuals wear contact lenses (CLs) worldwide and compared to non CL wearers, they exhibit a higher risks of eye infection and ocular inflammatory events. As CLs are evolving towards becoming diagnostic ... -
In Vitro Cornea Models in Contact Lens Based Ocular Drug Delivery
(University of Waterloo, 2016-07-28)The development of suitable in vitro release and diffusion models for contact lens-based drug delivery may lead to the establishment of in vitro/in vivo correlations. It is evident that an in vitro model that can reproduce ... -
In vitro evaluation of bone cell response to novel 3D-printable nanocomposite biomaterials for bone reconstruction
(University of Waterloo, 2022-01-25)Critical-sized segmental bone defects are a challenging problem for orthopedic surgeons. These defects are unable to heal spontaneously within a patient’s lifetime. Thus, biomaterials are used to repair such defects and ... -
The Phenotype of Tear Neutrophils and Their Role in Ocular Homeostasis and Inflammation
(University of Waterloo, 2023-07-31)Introduction: Neutrophils (polymorphonuclear neutrophils, PMNs) are part of the innate immune system with potent killing mechanisms against pathogens. Although the anterior segment of the eye has a unique characteristic, ... -
Protocol development for reliable isolation of tear-film neutrophils and in vitro functionality testing
(University of Waterloo, 2019-09-19)During prolonged eye closure, such as during sleep, leukocytes are recruited to the ocular surface, with polymorphonuclear neutrophils (PMNs) representing the largest population. PMNs are essential inflammatory cells ...