Browsing Theses by Subject "gene delivery"
Now showing items 1-5 of 5
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Biointerface Topography for Enhanced Nonviral Gene Delivery
(University of Waterloo, 2023-12-11)Substrate-mediated nonviral gene delivery (SMD) represents a burgeoning area of interest in the field of tissue engineering due to its potential to facilitate localized transfection while providing the scaffolding for ... -
Construction and characterization of a hybrid bacteriophage gene delivery platform
(University of Waterloo, 2022-04-26)Bacteriophages, viruses that specifically infect bacteria, may be considered as structurally simplistic protein-based vehicles for ferrying nucleic acid cargo. Since phages cannot infect nor replicate within human cells, ... -
Design, Characterization and Application of Amphipathic Peptides for siRNA Delivery
(University of Waterloo, 2013-01-25)Short interfering RNAs (siRNAs) are 21-23 nucleotide-long double-stranded RNA molecules that can trigger the RNA interference (RNAi). RNAi is a post-transcriptional gene silencing process whereby siRNAs induce the ... -
Mixed Micelle Characterization of Pluronic and Gemini Surfactant – Based Gene Therapy Carriers and a Connection to Transfection Efficiency
(University of Waterloo, 2020-09-16)Non-viral gene therapy formulation development often relies on a rational design approach, where vector components are selected based on individual characteristics known to favour transfection efficiency. However, these ... -
Stearylated Peptides for Therapeutic siRNA Delivery and Their Cellular Uptake Mechanisms
(University of Waterloo, 2015-10-15)Small interfering RNA (siRNA) shows great potential as a powerful tool in gene therapy, due to its ability to regulate gene expression in a highly selective manner. siRNA is a double-stranded RNA consisting of 21–23 ...