Browsing Theses by Subject "drug delivery"
Now showing items 1-15 of 15
-
Antifungal ocular drug delivery via contact lenses using a novel in vitro eye model
(University of Waterloo, 2016-04-21)Purpose: The purpose of this thesis was to evaluate the potential of contact lenses (CLs) as an antifungal drug delivery device, and to develop an in vitro eye model to test thereof. Methods: The first three chapters ... -
Arborescent Polypeptides for Sustained Drug Delivery Applications
(University of Waterloo, 2017-08-09)This Ph.D. dissertation describes the synthesis of arborescent copolymers of generations G1 and G2 designed to serve as drug delivery nanocarriers for cancer treatment. Poly(γ-benzyl L-glutamate) (PBG) building blocks were ... -
Cationic Lytic Peptides as Drugs or Drug Carriers for Targeted Cancer Therapy
(University of Waterloo, 2015-01-05)Cationic lytic peptides (CLPs) have emerged as new anticancer agents with a new mode of action. This category of peptides is given the characteristics of overall positive charges and amphiphilicity, inducing cell death by ... -
Curdlan 1,3-Beta-Glucans: A New Platform for Polymer Drug Delivery
(University of Waterloo, 2011-04-25)1,3-β-glucans are a class of natural polysaccharides with unique pharmacological properties and the ability to form triple helical structures and resilient gels. Curdlan and other 1,3-β-glucans have found application ... -
Development of a Novel, Microemulsion System for the Simultaneous Delivery of Hydrophilic and Hydrophobic Active Pharmaceutical Ingredients (APIs)
(University of Waterloo, 2020-09-28)Concurrent chronic disease and ensuing multi-morbidity are a debilitating reality for millions of Canadians. This adversity is compounded by increased pill burden and decreased patient adherence. Microemulsions (MEs) serve ... -
Development of Microparticles Created from Physically Modified Starch Granules for the Uptake and Release of Drugs
(University of Waterloo, 2021-01-07)Controlled release drug delivery systems are, depending on the desired effect, generally an improvement over conventional drug delivery. Through material design, drugs can be delivered with temporal and spatial control, ... -
Development of Modular Polymeric NPs for Drug Delivery Using Amine-Reactive Chemistry
(University of Waterloo, 2024-01-26)Cancer remains one of the leading causes of death worldwide and very often requires chemotherapy treatment. Despite advances in chemotherapy treatments, some cancers remain difficult to treat due to tumour type, location, ... -
Double Emulsion Mucoadhesive Nanoparticles for Hydrophilic Ocular Drug Delivery
(University of Waterloo, 2018-09-05)Common eye diseases such as conjunctivitis affect around 6 million people annually. Although eye drops are the most common treatment for these diseases, topical administration is limited by low ocular bioavailability due ... -
Evaluation of endothelial cell response to drug for intraocular lens delivery
(University of Waterloo, 2011-10-27)Cataract is one of the leading causes of vision loss worldwide. The rate of cataract surgery has been steadily increasing. Toxic Anterior Segment Syndrome (TASS) is a sterile inflammatory response in the anterior segment ... -
Modeling and Control of a Magnetic Drug Delivery System
(University of Waterloo, 2012-08-29)Therapeutic operation risk has been reduced by the use of micro-robots, allowing highly invasive surgery to be replaced by low invasive surgery (LIS), which provides an effective tool even in previously inaccessible parts ... -
Mucoadhesive Nanoparticles for Treatment of Influenza A
(University of Waterloo, 2017-08-31)Influenza A is the most pandemic-prone class of the influenza virus, with new strains emerging every year. Though vaccination is promoted as the vanguard against wide-spread infection, it is not enough to withstand mutating ... -
Multifunctional Nano MOF Particle for Anticancer Drug Delivery
(University of Waterloo, 2022-01-05)PCN-224 MOF nano particles were modified with a peptide named NPKMTX to deliver dox to cancer cells. -
PSEUDO-TERNARY PHASE DIAGRAMS OF A DRUG DELIVERY SYSTEM
(University of Waterloo, 2009-05-04)The purpose of this research was to develop the pseudo-ternary phase diagrams for a model drug delivery system consisting of vitamin E (model drug) + soybean oil + surfactant + co-surfactant (anhydrous glycerol) + water. ... -
Synthesis and Solution Properties of Water-soluble Fullerene Polymeric Systems
(University of Waterloo, 2011-09-20)Water-soluble fullerene containing polymers comprising of poly(2-(dimethylamino) ethyl methacrylate)-fullerene (PDMAEMA-C60) with targeting moieties, poly(oligo(ethylene glycol) methyl ether methacrylate)-C60 (POEGMA-C60), ... -
Synthesis of Polylactide-block-Poly(L-Lysine) Block Copolymers
(University of Waterloo, 2018-03-06)Polylactide (PLA) is an important biodegradable, biocompatible and renewable material that has been studied for many years for biomedical applications such as tissue scaffolding and surgical sutures. The research project ...