Browsing Theses by Subject "RNAi"
Now showing items 1-3 of 3
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Design, Characterization and Application of Amphipathic Peptides for siRNA Delivery
(University of Waterloo, 2013-01-25)Short interfering RNAs (siRNAs) are 21-23 nucleotide-long double-stranded RNA molecules that can trigger the RNA interference (RNAi). RNAi is a post-transcriptional gene silencing process whereby siRNAs induce the ... -
Investigating the Role of Deoxyhypusine Synthase in the Invasiveness of PC3 Cells Using siRNA
(University of Waterloo, 2008-08-11)Deoxyhypusine synthase (DHS) catalyzes the first step in the hypusination of eukaryotic translation initiation factor 5A (eIF5A). In human cells, two eIF5A isoforms are present, eIF5A-1 and eIF5A-2, and DHS catalyzes the ... -
Stearylated Peptides for Therapeutic siRNA Delivery and Their Cellular Uptake Mechanisms
(University of Waterloo, 2015-10-15)Small interfering RNA (siRNA) shows great potential as a powerful tool in gene therapy, due to its ability to regulate gene expression in a highly selective manner. siRNA is a double-stranded RNA consisting of 21–23 ...