Browsing Theses by Title
Now showing items 7322-7341 of 15535
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In vitro model for Fuchs Endothelial Dystrophy and its effects on corneal endothelial cells
(University of Waterloo, 2020-05-22)Fuchs endothelial dystrophy (FED), a corneal endothelium disease, is one of the leading causes for corneal transplantation. During disease progression, Descemet membrane’s (DM), the corneal endothelial basement membrane, ... -
An in vitro model of oxidative damage in bovine cortical bone to induce bone fragility
(University of Waterloo, 2021-08-19)Increased bone fragility can stem from age-related and chronic bone affecting diseases (such as osteoporosis, diabetes and kidney disease), chemotherapeutic and radiation-based cancer treatments, and/or trauma and results ... -
In Vitro Modelling of Fuchs Endothelial Dystrophy for Corneal Endothelial Cell Apoptosis and Characterization of Human Descemets Membrane
(University of Waterloo, 2024-04-18)The corneal endothelium is a terminally differentiated tissue that is typically considered non-proliferative in vivo. Corneal endothelial dystrophies, including Fuchs' endothelial dystrophy (FED), are a significant cause ... -
In Vitro NMR Study of Magnetization Exchange at Low Field and Proteoglycan-Depletion at High Field in Articular Cartilage
(University of Waterloo, 2016-06-30)Magnetization exchange between different spin reservoirs, or spin groups, in cartilage tissue is an important aspect of the use of Magnetic Resonance Imaging (MRI) in the early detection of osteoarthritis (OA). A low field ... -
In vitro regeneration of Bienertia sinuspersici
(University of Waterloo, 2010-09-02)This thesis presents a study on the development of plant regeneration protocols for Bienertia sinuspersici, one of three species of the family Chenopodiaceae that were discovered to perform C4 photosynthesis in individual ... -
In Vitro Release of Inflammatory Cytokines from Contact Lens Materials
(University of Waterloo, 2020-12-22)The upregulation of inflammatory mediators in the tear film during contact lens wear indicates that lens wear may induce an inflammatory response on the ocular surface. Previous research has investigated the relationship ... -
In vitro selection and biochemical characterization of trivalent metal ion dependent RNA-cleaving DNAzymes
(University of Waterloo, 2016-08-30)DNAzymes are DNA sequences with catalytic activity. So far, all known DNAzymes have been isolated using the high-throughput in vitro selection method. DNAzymes have been used for analytical, biomedical, and nanotechnology ... -
In Vitro Selection of New DNAzymes as Metal Biosensors
(University of Waterloo, 2015-06-26)In vitro selection of metal-specific DNAzymes has been shown to be a powerful method to obtain biosensors for metal ion detection. With 14 independent in vitro selection experiments using each of the trivalent lanthanide ... -
In Vitro Selection, Characterization, and Application of a Sodium-Dependent DNAzyme and a Metal-Independent Ribozyme
(University of Waterloo, 2021-09-20)Ribozymes and DNAzymes are collectively called catalytic nucleic acids. Compared to protein enzymes, catalytic nucleic acids are programmable in structure, easy to synthesize or modify, and more chemically stable especially ... -
In Vitro Studies of a New Radiosensitizer for Radiotherapy of Breast Cancer
(University of Waterloo, 2015-08-27)Breast cancer is the most commonly diagnosed cancer among women and is the leading cause of cancer death in both developing and developed areas. Triple-negative breast cancer, one of the subtypes of breast cancer, is ... -
In vitro Studies of Improvement in Treatment Efficiency of Photodynamic Therapy of Cancers through Near-Infrared/Bioluminescent Activation
(University of Waterloo, 2014-05-22)Cancer is a leading cause of death that affects millions of people across the globe each year. Photodynamic therapy (PDT) is a relatively new treatment approach for cancer in which anticancer drugs are activated by light ... -
In vitro studies of NOS inhibitors using purified human NOS isozymes
(University of Waterloo, 2017-12-18)Endogenous nitric oxide (NO) is derived from L-arginine via a chemical reaction catalyzed by nitric oxide synthases (NOS). Three NOS isozymes are found in humans: neuronal NOS (nNOS), endothelial NOS (eNOS) and inducible ... -
In vitro test of a potential hypoxic radiosensitizer
(University of Waterloo, 2016-09-28)Oxygen has long been known as a potent radiosensitizer that can enhance the cell killing effects in aerobic cells, while pruned vasculatures and lack of oxygen in the microenvironment of tumor can cause resistance to ... -
In Vivo Calibration Methods of SPME and Application to Pharmacokinetic Studies
(University of Waterloo, 2009-05-21)Solid phase microextraction (SPME) has gained much popularity for in vivo applications recently. Thus far, there are two types of pre-equilibrium kinetic calibration that have been applied to in vivo SPME: on-fibre ... -
In Vivo Detection of Trace Organic Contaminants in Fish Using Solid Phase Microextraction
(University of Waterloo, 2010-10-21)The feasibility of using solid phase micro-extraction (SPME) as an in vivo sampling tool for analysis of trace environmental contaminants in fish exposed to municipal wastewater effluents (MWWEs) was validated using ... -
IN VIVO EPIGENETIC STUDY OF HISTONE ACETYLATION ASSOCIATED WITH OBESITY
(University of Waterloo, 2007-10-02)Post translational modifications in histone proteins are transmissible changes that are not coded for in the DNA sequence itself but have a significant affect in the control of gene expression. Eukaryotic transcription is ... -
In Vivo Imaging of Corneal Conditions using Optical Coherence Tomography
(University of Waterloo, 2006)Purposes: To use optical coherence tomography (OCT) to image and quantify the effect of various corneal conditions, in terms of corneal, stromal and epithelial thickness, and light backscatter. To assess the changes ... -
In vivo Imaging of Light Induced Intrinsic Optical Signals in the Chicken Retina with a Combined Ultra-High Resolution Optical Coherence Tomography and Electroretinography System
(University of Waterloo, 2013-01-15)The main objective of this thesis is to investigate the intrinsic optical signals (IOSs) with an ultra-high resolution optical coherence tomography system (UHROCT). In order to study the retinal IOSs evoked by visible ... -
In vivo Solid Phase Microextraction for Brain Tissue Analysis
(University of Waterloo, 2014-03-31)New solid phase microextraction (SPME) method was developed for brain tissue bioanalysis on a liquid chromatography mass spectrometry platform. To achieve set objectives, in vivo SPME desorption process was optimized for ... -
“In Works of Hands or of the Wits of Men”: The Elegies of Wim Wenders, Laurie Anderson and Alexander Sokurov
(University of Waterloo, 2019-04-22)This dissertation explores the concept of loss and the possibility of consolation in Wim Wenders’s The Salt of the Earth, Laurie Anderson’s Heart of a Dog and Alexander Sokurov’s Oriental Elegy through a method that ...