Browsing Theses by Title
Now showing items 13447-13466 of 15526
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Statistical Methods for High Throughput Screening Drug Discovery Data
(University of Waterloo, 2005)High Throughput Screening (HTS) is used in drug discovery to screen large numbers of compounds against a biological target. Data on activity against the target are collected for a representative sample of compounds ... -
Statistical Methods for Incomplete Covariates and Two-Phase Designs
(University of Waterloo, 2013-01-24)Incomplete data is a pervasive problem in health research, and as a result statistical methods enabling inference based on partial information play a critical role. This thesis explores estimation of regression coefficients ... -
Statistical Methods for Large-scale Multiple Testing Problems
(University of Waterloo, 2019-04-26)A large-scale multiple testing problem simultaneously tests thousands or even millions of null hypotheses, and it is widely used in different fields, for example genetics and astronomy. An error rate serves as a measure ... -
Statistical Methods for Life History Analysis Involving Latent Processes
(University of Waterloo, 2014-05-22)Incomplete data often arise in the study of life history processes. Examples include missing responses, missing covariates, and unobservable latent processes in addition to right censoring. This thesis is on the development ... -
Statistical Methods for Multi-State Analysis of Incomplete Longitudinal Data
(University of Waterloo, 2008-09-25)Analyses of longitudinal categorical data are typically based on semiparametric models in which covariate effects are expressed on marginal probabilities and estimation is carried out based on generalized estimating ... -
Statistical Methods in the Search for a Dominant Cause of Variation
(University of Waterloo, 2023-12-15)Excessive variation in critical-to-quality characteristics, referred to as process outputs in this thesis, is a common issue in manufacturing industries. Most variation reduction frameworks initially investigate the process ... -
Statistical Methods on Survival Data with Measurement Error
(University of Waterloo, 2014-08-25)In survival data analysis, covariates are often subject to measurement error. A naive analysis with measurement error ignored commonly leads to biased estimation of parameters of survival models. Measurement error also ... -
Statistical Model-Based Corneal Reconstruction
(University of Waterloo, 2013-12-10)Precise measurements of corneal layer thickness are required to treat, evaluate risk of, and determine the progression of pathologies within the eye. The thickness measurements are typically acquired as 2d images, known ... -
Statistical Modeling of Fracture Toughness Data
(University of Waterloo, 2007-09-25)The fracture toughness of the zirconium alloy (Zr-2.5Nb) is an important parameter in determining the flaw tolerance for operation of pressure tubes in reactor. Fracture toughness data have been generated by performing ... -
Statistical Models and Methods for Dependent Life History Processes
(University of Waterloo, 2018-11-28)This thesis deals with statistical issues in the analysis of complex life history processes which have characteristics of heterogeneity and dependence. We are motivated, in this thesis, by three specific types of ... -
Statistical Muon Tracking: A Study of Cosmic Backgrounds in the PROSPECT Experiment
(University of Waterloo, 2021-09-30)The Precision Reactor Oscillation and Spectrum Experiment (PROSPECT) has successfully demonstrated novel particle identification strategies with minimal protection from cosmic events. Located at the High Flux Isotope Reactor ... -
Statistical Power in Ergonomic Intervention Studies
(University of Waterloo, 2010-04-21)As awareness of the costs of workplace injury and illness continues to grow, there has been an increased demand for effective ergonomic interventions to reduce the prevalence of musculoskeletal disorders (MSDs). The goal ... -
A Statistical Response to Challenges in Vast Portfolio Selection
(University of Waterloo, 2019-07-04)The thesis is written in response to emerging issues brought about by an increasing number of assets allocated in a portfolio and seeks answers to puzzling empirical findings in the portfolio management area. Over the ... -
Statistical Sample Size Determination Methods for Inspections of Engineering Systems
(University of Waterloo, 2018-12-18)A statistical sample size determination (SSD) method is designed for the maintenance of engineering components of similar structure within an overall system. The maintenance problem is defined as a sequential decision-making ... -
Statistical Techniques and Non-Destructive Testing Methods for Copper Wire Bond Reliability Investigation
(University of Waterloo, 2018-09-19)Microelectronic devices require packaging for mechanical protection and electrical interconnections. Reliability challenges in microelectronics packaging are becoming more severe, as applications demand smaller package ... -
Statistical Variability Analysis of SilGeo
(University of Waterloo, 2023-12-18)The electronics manufacturing and supply industry is rife with the unchecked circulation of counterfeit and tampered components. Although developments have been made to counter this issue, the methods often involve visual ... -
Statistical Yield Analysis and Design for Nanometer VLSI
(University of Waterloo, 2010-08-20)Process variability is the pivotal factor impacting the design of high yield integrated circuits and systems in deep sub-micron CMOS technologies. The electrical and physical properties of transistors and interconnects, ... -
A Statistically Rigorous Evaluation of the Cascade Bloom Filter for Distributed Access Enforcement in Role-Based Access Control (RBAC) Systems
(University of Waterloo, 2011-01-20)We consider the distributed access enforcement problem for Role-Based Access Control (RBAC) systems. Such enforcement has become important with RBAC’s increasing adoption, and the proliferation of data that needs to be ... -
Steady-State Analysis and Optimal Power Routing of Standalone Unbalanced Hybrid AC/DC Microgrids
(University of Waterloo, 2018-08-03)The concept of ac microgrids was introduced to integrate distributed generators (DGs) and loads within one entity that can operate autonomously or connected to a utility grid. Furthermore, dc microgrids have received ... -
Steam Gasification of Excavated Waste Residue (EWR) from a Landfill Bioreactor Operated Under cold Climate Conditions
(University of Waterloo, 2022-09-28)The use of fossil fuel to generate energy has contributed to the emission of greenhouse gases, which is a leading factor in the depletion of the ozone layer. This effect of fossil fuel on the atmosphere has led to the push ...