Browsing Theses by Title
Now showing items 7322-7341 of 15526
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In Vitro Selection of New DNAzymes as Metal Biosensors
(University of Waterloo, 2015-06-26)In vitro selection of metal-specific DNAzymes has been shown to be a powerful method to obtain biosensors for metal ion detection. With 14 independent in vitro selection experiments using each of the trivalent lanthanide ... -
In Vitro Selection, Characterization, and Application of a Sodium-Dependent DNAzyme and a Metal-Independent Ribozyme
(University of Waterloo, 2021-09-20)Ribozymes and DNAzymes are collectively called catalytic nucleic acids. Compared to protein enzymes, catalytic nucleic acids are programmable in structure, easy to synthesize or modify, and more chemically stable especially ... -
In Vitro Studies of a New Radiosensitizer for Radiotherapy of Breast Cancer
(University of Waterloo, 2015-08-27)Breast cancer is the most commonly diagnosed cancer among women and is the leading cause of cancer death in both developing and developed areas. Triple-negative breast cancer, one of the subtypes of breast cancer, is ... -
In vitro Studies of Improvement in Treatment Efficiency of Photodynamic Therapy of Cancers through Near-Infrared/Bioluminescent Activation
(University of Waterloo, 2014-05-22)Cancer is a leading cause of death that affects millions of people across the globe each year. Photodynamic therapy (PDT) is a relatively new treatment approach for cancer in which anticancer drugs are activated by light ... -
In vitro studies of NOS inhibitors using purified human NOS isozymes
(University of Waterloo, 2017-12-18)Endogenous nitric oxide (NO) is derived from L-arginine via a chemical reaction catalyzed by nitric oxide synthases (NOS). Three NOS isozymes are found in humans: neuronal NOS (nNOS), endothelial NOS (eNOS) and inducible ... -
In vitro test of a potential hypoxic radiosensitizer
(University of Waterloo, 2016-09-28)Oxygen has long been known as a potent radiosensitizer that can enhance the cell killing effects in aerobic cells, while pruned vasculatures and lack of oxygen in the microenvironment of tumor can cause resistance to ... -
In Vivo Calibration Methods of SPME and Application to Pharmacokinetic Studies
(University of Waterloo, 2009-05-21)Solid phase microextraction (SPME) has gained much popularity for in vivo applications recently. Thus far, there are two types of pre-equilibrium kinetic calibration that have been applied to in vivo SPME: on-fibre ... -
In Vivo Detection of Trace Organic Contaminants in Fish Using Solid Phase Microextraction
(University of Waterloo, 2010-10-21)The feasibility of using solid phase micro-extraction (SPME) as an in vivo sampling tool for analysis of trace environmental contaminants in fish exposed to municipal wastewater effluents (MWWEs) was validated using ... -
IN VIVO EPIGENETIC STUDY OF HISTONE ACETYLATION ASSOCIATED WITH OBESITY
(University of Waterloo, 2007-10-02)Post translational modifications in histone proteins are transmissible changes that are not coded for in the DNA sequence itself but have a significant affect in the control of gene expression. Eukaryotic transcription is ... -
In Vivo Imaging of Corneal Conditions using Optical Coherence Tomography
(University of Waterloo, 2006)Purposes: To use optical coherence tomography (OCT) to image and quantify the effect of various corneal conditions, in terms of corneal, stromal and epithelial thickness, and light backscatter. To assess the changes ... -
In vivo Imaging of Light Induced Intrinsic Optical Signals in the Chicken Retina with a Combined Ultra-High Resolution Optical Coherence Tomography and Electroretinography System
(University of Waterloo, 2013-01-15)The main objective of this thesis is to investigate the intrinsic optical signals (IOSs) with an ultra-high resolution optical coherence tomography system (UHROCT). In order to study the retinal IOSs evoked by visible ... -
In vivo Solid Phase Microextraction for Brain Tissue Analysis
(University of Waterloo, 2014-03-31)New solid phase microextraction (SPME) method was developed for brain tissue bioanalysis on a liquid chromatography mass spectrometry platform. To achieve set objectives, in vivo SPME desorption process was optimized for ... -
“In Works of Hands or of the Wits of Men”: The Elegies of Wim Wenders, Laurie Anderson and Alexander Sokurov
(University of Waterloo, 2019-04-22)This dissertation explores the concept of loss and the possibility of consolation in Wim Wenders’s The Salt of the Earth, Laurie Anderson’s Heart of a Dog and Alexander Sokurov’s Oriental Elegy through a method that ... -
In-between Boundaries
(University of Waterloo, 2016-09-27)While the highway infrastructure of North America provides great benefits by connecting both urban and rural communities, this infrastructure also comes with significant costs by separating and creating barriers between ... -
An In-Depth Exploration of the High-Quality Entity Linking for Information Retrieval: MMEAD
(University of Waterloo, 2023-12-19)Entity linking has emerged significantly during the digital information explosion, aiming to provide context and meaning to huge amounts of unstructured data. While traditional information retrieval primarily relied on ... -
An In-Depth Look at Repeated Propagation of Multiple Viruses Simultaneously in Insect Cell Culture
(University of Waterloo, 2020-01-22)It is well known that the insect cell-baculovirus expression vector system (IC-BEVS) can be used for the production of various proteins of interest and virus-like particles (VLPs). In the past, many higher order proteins ... -
In-Memory Storage for Labeled Tree-Structured Data
(University of Waterloo, 2017-03-16)In this thesis, we design in-memory data structures for labeled and weights trees, so that various types of path queries or operations can be supported with efficient query time. We assume the word RAM model with word size ... -
In-network computation in sensor networks
(University of Waterloo, 2012-12-07)Sensor networks are an important emerging class of networks that have many applications. A sink in these networks acts as a bridge between the sensor nodes and the end-user (which may be automated and/or part of the ... -
In-Network Scheduling for Real-Time Analytics
(University of Waterloo, 2021-04-30)This thesis presents Bolt, a novel scheduler design for large-scale real-time data analytics. Bolt achieves the scheduling accuracy of modern centralized schedulers while supporting clusters with hundreds of thousands of ... -
In-Silico Methods for De-Risking the Clinical Development of Subcutaneously Administered Therapeutic Macromolecules
(University of Waterloo, 2016-07-27)Prediction of human pharmacokinetics (PK) following subcutaneous (SC) administration to animals is challenged by potential interspecies differences in skin anatomy and physiology. With respect to biologic or macromolecule ...