Browsing University of Waterloo by Supervisor "Palmer, Michael"
Now showing items 1-3 of 3
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Action Mechanism and Structural Studies on the Lipopeptide Antibiotic Daptomycin
(University of Waterloo, 2019-07-02)Daptomycin (dap) is calcium-dependent lipopeptide antibiotic that is used clinically to treat systemic infections caused by Gram-positive pathogens. It is thought that dap brings about its antimicrobial effect by binding ... -
Daptomycin: studies on its action mode and on bacterial resistance with model membranes
(University of Waterloo, 2016-05-16)Bacterial resistance to antibiotics is one of the most serious problems facing medicine today. Recently, reports have appeared describing bacteria that are resistant to daptomycin (dap), an important antibiotic used against ... -
Streptococcus agalactiae CAMP factor: Functional Roles of N- and C-terminal Domains & Target Membrane Effect on Toxin Activity
(University of Waterloo, 2018-05-22)CAMP factor is a well-known pore-forming toxin secreted by Streptococcus agalactiae that forms discrete pores on susceptible membranes whether natural or artificial. This work reports haemolysis and liposome permeabilization ...