Browsing University of Waterloo by Supervisor "Nekkar, Praveen"
Now showing items 1-5 of 5
-
3-Phenylpyrazino[1,2-a]indol-1(2H)-ones as dual cholinesterase and amyloid aggregation inhibitors
(University of Waterloo, 2017-05-10)The year 2017, marks the 110th anniversary of the discovery of Alzheimer’s disease (AD)- a devastating neurodegenerative disease. Regardless of the significant advances made in the past century on the pathology of AD, the ... -
Design, Synthesis and Biological Evaluation of Novel Adamantane Derivatives as Potential Treatments for Alzheimer’s Disease
(University of Waterloo, 2017-02-14)Alzheimer’s disease (AD) is a complex, multifactorial, and rapidly neurodegenerative disorder characterized by cognitive impairment and progressive dementia. Its pathology was first characterized by Alois Alzheimer as “a ... -
Multi-Targeting Derivatives For Alzheimer’s Disease: Utilization of Quinazoline Ring Scaffolds
(University of Waterloo, 2016-08-30)The complex and multifaceted nature of Alzheimer’s pathology has significantly hindered the discovery and development of viable therapeutics, let alone the cause and initiation of the disease. Over the past century, what ... -
Piperine Derivatives as Modulators of Amyloid-Beta (Aβ) Aggregation
(University of Waterloo, 2023-07-12)Alzheimer’s Disease (AD) is a life-changing neurodegenerative disease that progresses in stages and currently has no effective cure. More than 597,000 Canadians suffer from AD. Symptoms of late-stage AD are severe and ... -
Understanding the dynamics and molecular interactions of the human cannabinoid receptor 1
(University of Waterloo, 2022-08-23)Cannabinoid receptor 1 (CB1), one of the most populated G-protein coupled receptors (GPCR) present within the brain, is involved in various physiological and homeostatic processes. These pathways include metabolism and ...