Now showing items 1-5 of 5

    • Biochemical Characterization of Fluorophore-Binding Nucleic Acids 

      Tormann, Alexandra (University of Waterloo, 2022-09-27)
      Aptamers, single stranded RNA or DNA that bind to target ligands with high affinity and specificity, have a wide range of applications, from therapeutics to biosensing, which makes biochemical characterization of the utmost ...
    • Determining the Structures and Properties of Biologically-relevant Ions 

      Psutka, Jarrod (University of Waterloo, 2018-08-09)
      Gas phase studies of biologically relevant ions are increasing in popularity due to the possibility of high throughput analysis requiring minimum sample concentrations. This thesis explores the potential of differential ...
    • Investigation of the Presence of a G-quadruplex In the Hoechst Dye Binding DNA Aptamer 

      Egerdeen, Kyla (University of Waterloo, 2022-04-22)
      Aptamers are nucleic acid sequences that have been selected to bind to a ligand with high affinity and selectivity. Aptamers have great potential for use in various biotechnological and medical applications but understanding ...
    • NMR Studies of Protein and Peptide Structure and Dynamics 

      Piazza, Michael (University of Waterloo, 2016-04-18)
      Calmodulin (CaM) is a small, acidic cytosolic calcium binding protein that responds to increases in intracellular Ca2+ concentrations. It is proposed to be involved in binding to and regulating over 300 functionally and ...
    • Studying the Structure and Kinetics of Functional Nucleic Acids 

      Piccolo, Kyle (University of Waterloo, 2021-09-30)
      Aptamers are valuable tools in a variety of biotechnological applications, ranging from biosensing to in vivo cell imaging. Studying these molecules can further our understanding of the structure and kinetics of nucleic ...


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