Browsing University of Waterloo by Subject "protein"
Now showing items 1-16 of 16
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Adnectin Solubility and Dynamics
(University of Waterloo, 2019-10-28)Rapid growth of the global market for monoclonal antibodies (mAbs) has generated considerable interest in the development of alternative molecules that facilitate rapid discovery and manufacturing, while replicating the ... -
An Assessment of Pyridoxine as a Biological Response Modifier During Colon Carcinogenesis
(University of Waterloo, 2007-10-05)The main objective of this proposal was to investigate the effect of vitamin B6 on colon carcinogenesis in vivo. Two in vivo studies were conducted to determine the role of vitamin B6 as a biological modifier of colon ... -
Characterization of Novel Protease Flagellinolysin in Pseudoalteromonas tunicata
(University of Waterloo, 2024-01-03)Flagellinolysins are a family of novel enzymes that act both as structural flagellins and proteases. Although previously identified and shown to be both structurally integrated into filaments and proteolytically active, ... -
Consensus Fold Recognition by Predicted Model Quality
(University of Waterloo, 2005)Protein structure prediction has been a fundamental challenge in the biological field. In this post-genomic era, the need for automated protein structure prediction has never been more evident and researchers are now ... -
Discovery and Analysis of Aligned Pattern Clusters from Protein Family Sequences
(University of Waterloo, 2014-04-28)Protein sequences are essential for encoding molecular structures and functions. Consequently, biologists invest substantial resources and time discovering functional patterns in proteins. Using high-throughput technologies, ... -
A droplet-based microfluidic platform for rapid immobilization of quantum dots on individual magnetic microbeads
(Springer Nature, 2018-06-01)Quantum dots (QDs) provide opportunities for the development of bioassays, biosensors, and drug delivery strategies. Decoration of the surface of QDs offers unique functions such as resistance to non-specific adsorption, ... -
Engineering Applications of Surface Plasmon Resonance: Protein–Protein and Protein–Molecule Interactions
(University of Waterloo, 2011-09-29)Protein-protein and protein-molecule interactions are complicated phenomena due to the tendency of proteins to change shape and function in response to their environment. Protein aggregation whether onto surfaces or in ... -
Functional Study of a Protein (UnkG) in Pseudomonas putida UW4
(University of Waterloo, 2011-07-20)The role played by the protein UnkG from the plant growth-promoting bacterium Pseudomonas putida UW4 in the ability of the bacterium to facilitate plant growth was studied. Previous work showed that over-expressing UnkG ... -
Identification of Factors Limiting Heterologous Lipase Expression in the Cytoplasm and the Periplasm as well as Display on Cell Surface of Escherichia coli
(University of Waterloo, 2008-08-07)Lipase B from Pseudozyma antarctica (PalB), had been expressed in several recombinant protein hosts and showed very good transesterification activity for biodiesel production. However, the functional expression could not ... -
Investigation of β-xylosidase, α-L-arabinofuranosidase and acetylesterase from Thermotoga hypogea
(University of Waterloo, 2008-09-03)Hemicellulases are key components in the degradation of plant biomass and carbon flow in nature. Thermotoga hypogea is a bacterium that can grow anaerobically at 90°C. It utilizes carbohydrates and peptides as energy and ... -
Minimal model for the secondary structures and conformational conversions in proteins
(University of Waterloo, 2005)Better understanding of protein folding process can provide physical insights on the function of proteins and makes it possible to benefit from genetic information accumulated so far. Protein folding process normally ... -
OEP15-1 and OEP7.3 Localize to the Outer Envelope of Chloroplasts Using a Novel and Uncharacterized Targeting Pathway
(University of Waterloo, 2021-09-27)Chloroplasts originated from an endosymbiotic event where a Gram-negative cyanobacterium was engulfed by an ancestral eukaryotic cell. The genome of the endosymbiont has since gone through extensive gene transfer to the ... -
Optical Biosensing Using Localized Surface Plasmon Resonance of Gold Nanoparticles
(University of Waterloo, 2011-05-25)This thesis describes some experiments developed to probe the fundamental aspects of the interfacial behaviour of proteins. The contents of this thesis can be broadly divided into two parts. In the first part, we ... -
Protein Deposition and Bacterial Adhesion to Conventional and Silicone Hydrogel Contact Lens Materials
(University of Waterloo, 2009-04-27)Introduction Contact lenses suffer from the same problems of deposition that other biomaterials exhibit, being rapidly coated with a variety of proteins, lipids and mucins. The first event observed at the interface between ... -
Protein Loop Prediction by Fragment Assembly
(University of Waterloo, 2007-01-19)If the primary sequence of a protein is known, what is its three-dimensional structure? This is one of the most challenging problems in molecular biology and has many applications in proteomics. During the last three ... -
Selected Experiments with Proteins at Solid-Liquid Interfaces
(University of Waterloo, 2008-12-12)This thesis describes a number of novel experiments contributing to the understanding of protein adsorption from both a fundamental and applied perspective. The first three papers involve the use of the localized surface ...