Browsing University of Waterloo by Subject "nitric oxide"
Now showing items 1-4 of 4
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Endothelium-dependent vasomotor responses of hypertensive and type 2 diabetic rats: effects of sex, ageing, and therapeutic interventions
(University of Waterloo, 2009-08-26)Impaired endothelial vasomotor function is a hallmark of many chronic disease states, including essential hypertension and type 2 diabetes mellitus. Loss of the homeostatic role of the endothelium in large conduit arteries ... -
In vitro studies of NOS inhibitors using purified human NOS isozymes
(University of Waterloo, 2017-12-18)Endogenous nitric oxide (NO) is derived from L-arginine via a chemical reaction catalyzed by nitric oxide synthases (NOS). Three NOS isozymes are found in humans: neuronal NOS (nNOS), endothelial NOS (eNOS) and inducible ... -
Influence of acute and chronic glutathione manipulations on coronary vascular resistance and endothelium dependent dilation in isolated perfused rat hearts
(University of Waterloo, 2011-01-25)Glutathione (GSH), a 3-amino acid compound is ubiquitously expressed in eukaryotic cells and is the most abundant low molecular weight thiol. The importance of GSH is highlighted by its multitude of effects. Within the ... -
Mechanisms of over-active endothelium-derived contracting factor signaling causing common carotid artery endothelial vasomotor dysfunction in hypertension and aging
(University of Waterloo, 2011-03-09)Background and Purpose: The endothelium is a single-cell layer positioned at the blood-vascular wall interface, where in response to blood-borne signals and hemodynamic forces, endothelial cells act as central regulators ...