Browsing University of Waterloo by Title
Now showing items 3937-3956 of 18727
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Design, Optimization, and Experimental Characterization of a Novel Magnetically Actuated Finger Micromanipulator
(University of Waterloo, 2018-09-20)The ability of external magnetic fields to precisely control micromanipulator systems has received a great deal of attention from researchers in recent years due to its off-board power source. As these micromanipulators ... -
Design, Prototyping, and Testing of an In-Wheel Suspension System
(University of Waterloo, 2009-09-30)This thesis presents a study of a novel suspension system which is placed inside a vehicle's wheel. The In-wheel suspension system isolates the sprung mass from excitations similar to conventional suspension systems. In ... -
Design, Simulation and Fabrication of Photonic Crystal Slab Waveguide Based Polarization Processors
(University of Waterloo, 2009-05-22)The Photonic Crystal (PC) is a potential candidate for a compact optical integrated circuit on a solid state platform. The fabrication process of a PC is compatible with CMOS technology; thus, it could be potentially ... -
Design, Synthesis and Biological Evaluation of 2,4-Disubstituted Pyrimidine Derivatives: Multifunctional Candidates as Potential Treatment Options for Alzheimer’s Disease
(University of Waterloo, 2011-08-30)Alzheimer’s disease (AD) is a highly complex and rapidly progressive neurodegenerative disorder characterized by the systemic collapse of cognitive function and formation of dense amyloid-β (Aβ) plaques and neurofibrillary ... -
Design, Synthesis and Biological Evaluation of Novel Adamantane Derivatives as Potential Treatments for Alzheimer’s Disease
(University of Waterloo, 2017-02-14)Alzheimer’s disease (AD) is a complex, multifactorial, and rapidly neurodegenerative disorder characterized by cognitive impairment and progressive dementia. Its pathology was first characterized by Alois Alzheimer as “a ... -
Design, synthesis and biological evaluation of novel tricyclics as dual cholinesterase (ChE) and amyloid aggregation inhibitors with antioxidant properties
(University of Waterloo, 2014-12-12)Alzheimer’s disease (AD) is a complex neurodegenerative disease affecting the cholinergic region of the brain. Its prevalence is steadily increasing and it is becoming one of the highest costing diseases to modern society. ... -
Design, Synthesis and Characterization of a Series of Self-assembling Polypeptides
(University of Waterloo, 2007-05-24)A series of polypeptides with well-defined sequences, (Asp3Phe1)n, (Asp2Phe1)n, (Asp1Phe1)n, (Asp1Phe2)n, and (Asp1Phe3)n, containing the hydrophilic amino acid, aspartic acid (Asp) and the hydrophobic amino acid, phenylalanine ... -
Design, synthesis, and evaluation of inhibitors of steroid sulfatase
(University of Waterloo, 2014-04-22)Steroid sulfatase (STS) catalyzes the desulfation of biologically inactive sulfated steroids to yield biologically active desulfated steroids and is currently being examined as a target for therapeutic intervention for the ... -
Design, Synthesis, and Evaluation of Tacrine-Based Derivatives: Potential Agents to Treat Alzheimer’s Disease
(University of Waterloo, 2013-08-01)With the incidence of Alzheimer’s disease (AD) growing worldwide and in Canada along with the growing economic and social burdens, the need for more effective therapies becomes of great importance. Since the discovery of ... -
Design, Synthesis, and Structure of Lithium Ion Conducting Materials for All-Solid-State Batteries
(University of Waterloo, 2021-06-24)Energy storage plays a pivotal role in enabling intermittent renewable energy sources, electrified transportation, and portable electronics. The rapidly growing energy demand in these sectors requires improvement to the ... -
Designing a Foot Input System for Productive Work at a Standing Desk
(University of Waterloo, 2015-03-13)In this thesis we present Tap-Kick-Click, a foot interaction system for controlling common desktop applications. This system enables computer workers to take healthy and productive breaks from using a keyboard and mouse ... -
Designing a living barrier fortifying the coast against extreme climate events to reharmonize the identity of people, land, and water on the Island of Efate, Vanuatu
(University of Waterloo, 2023-03-24)On the Pacific island of Vanuatu, the connection the islanders have nurtured with the land and water is both evident and fundamental to their conception of life and legacy -the spirits of their ancestors are thought to ... -
Designing a Privacy-Aware Location Proof Architecture
(University of Waterloo, 2010-04-15)Although location-based applications have existed for several years, verifying the correctness of a user's claimed location is a challenge that has only recently gained attention in the research community. Existing ... -
Designing a Real-Time Grid Simulator for use in Market and A.G.C. Studies
(University of Waterloo, 2008-09-03)Market based generation dispatch is becoming the industry norm in advanced electrical jurisdictions. Due to the continuous evolution of markets and their potential impacts on system operation, studies are performed from ... -
Designing a System for Measuring and Optimizing the Photothermal Conversion Efficiencies of Two Dimensional Nanomaterials for Cancer Therapy
(University of Waterloo, 2021-09-21)Cancer is a devastating disease with no definitive cure currently. Current treatments are invasive and can cause inreprepable damage to the human body. Alternative cancer treatment methods involving nanomaterials have ... -
Designing a Unity Plugin to Predict Expected Affect in Games Using Biophilia
(University of Waterloo, 2022-09-28)Video games can generate different emotional states and affective reactions, but it can sometimes be difficult for a game’s visual designer to predict the emotional response a player might experience when designing a game ... -
Designing an Adaptive Video Game for Children with Attention Deficit Hyperactivity Disorder: Learning Proportional Reasoning through Play
(University of Waterloo, 2018-11-30)Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder marked by symptoms of inattention and/or hyperactivity and impulsivity. Many children with ADHD suffer from poor reasoning and decision-making ... -
Designing an Architecture of Labour Affirmation, Harm Reduction and Community Development for Vancouver's Sex Worker Population
(University of Waterloo, 2022-08-26)Within the current political, social, and legal landscape of Canada, sex workers face a considerable number of barriers to labour recognition that would afford them labour rights, dignity, and safety. The refusal to accept ... -
Designing an Incentive-compatible Reward Scheme for Algorand
(University of Waterloo, 2022-06-21)Founded in 2017, Algorand is the first carbon-negative blockchain protocol inspired by proof of stake. Algorand uses a Byzantine agreement protocol to add new blocks to the blockchain. The protocol can tolerate malicious ... -
Designing and Delivering Interactive, Simulator-based Aviation Research Studies on the Web
(University of Waterloo, 2015-09-01)Traditionally, interactive, simulator-based aviation research studies have been conducted in physical labs. However, the internet has allowed researchers to deliver experiments via web platforms, thus gaining the ability ...