Browsing University of Waterloo by Author "Da Costa, Jason B."
Now showing items 1-4 of 4
-
Catalytic Potential and Ligand Binding Properties of the Malachite Green RNA Aptamer
Da Costa, Jason B. (University of Waterloo, 2008-09-18)The malachite green aptamer was originally engineered for binding specificity to malachite green (MG). The environment inside the aptamer’s electronegative binding pocket was previously harnessed to catalyze an ester ... -
Exploring Ligand Structure and Thermodynamics of the Malachite Green RNA Aptamer
Da Costa, Jason B. (University of Waterloo, 2012-01-20)RNA aptamers are in vitro sequences of RNA that have a high affinity for their target ligand. They have applications in therapeutics, biosensors and molecular machines. While the practical applications of aptamers are ... -
Structure and Thermodynamics of Drug-RNA Aptamer Interactions
Da Costa, Jason B.; Dieckmann, Thorsten (Bentham Science Publishers, 2013-03-01)This mini-review will provide an overview on the recent studies of structure and thermodynamics of RNA aptamers that target drug molecules. These aptamers are studied to provide insight into RNA drug interactions. This ... -
Thermodynamics and Kinetics of Adaptive Binding in the Malachite Green RNA Aptamer
Da Costa, Jason B.; Andreiev, Aurelia I.; Dieckmann, Thorsten (American Chemical Society, 2013-09-24)Adaptive binding, the ability of molecules to fold themselves around the structure of a ligand and thereby incorporating it into their three-dimensional fold, is a key feature of most RNA aptamers. The malachite green ...