Browsing University of Waterloo by Author "Seimbille, Yann"
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Early-Stage Incorporation Strategy for Regioselective Labeling of Peptides using the 2-Cyanobenzothiazole/1,2-Aminothiol Bioorthogonal Click Reaction
Chen, Kuo-Ting; Ieritano, Christian; Seimbille, Yann (Wiley, 2018-03)Herein, we describe a synthetic strategy for the regioselective labeling of peptides by using a bioorthogonal click reaction between 2‐cyanobenzothiazole (CBT) and a 1,2‐aminothiol moiety. This methodology allows for the ... -
A Flexible Synthesis of 68Ga-Labeled Carbonic Anhydrase IX (CAIX)-Targeted Molecules via CBT/1,2-Aminothiol Click Reaction
Chen, Kuo-Ting; Nguyen, Kevin; Ieritano, Christian; Gao, Feng; Seimbille, Yann (MDPI, 2018-12-21)We herein describe a flexible synthesis of a small library of 68Ga-labeled CAIX-targeted molecules via an orthogonal 2-cyanobenzothiazole (CBT)/1,2-aminothiol click reaction. Three novel CBT-functionalized chelators (1–3) ...