Browsing University of Waterloo by Author "Cook, Richard"
Now showing items 1-20 of 43
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Analysis of interval-censored recurrent event processes subject to resolution
Cook, Richard J.; Shen, Hua (Wiley, 2015-09)Interval-censored recurrent event data arise when the event of interest is not readily observed but the cumulative event count can be recorded at periodic assessment times. In some settings, chronic disease processes may ... -
Assessing the accuracy of predictive models with interval-censored data
Wu, Ying; Cook, Richard (Oxford University Press, 2022-01)We develop methods for assessing the predictive accuracy of a given event time model when the validation sample is comprised of case K interval-censored data. An imputation-based, an inverse probability weighted (IPW), and ... -
Augmented composite likelihood for copula modeling in family studies under biased sampling
Zhong, Yujie; Cook, Richard J. (Oxford University Press, 2016-01-27)The heritability of chronic diseases can be effectively studied by examining the nature and extent of within-family associations in disease onset times. Families are typically accrued through a biased sampling scheme in ... -
Classical regression and predictive modeling
Cook, Richard; Lee, Ker-Ai; Lo, Benjamin W.Y.; Macdonald, R. Loch (Elsevier, 2022-05)BACKGROUND: With the advent of personalized and stratified medicine, there has been much discussion about predictive modeling and the role of classical regression in modern medical research. We describe and distinguish the ... -
Cohort study design for illness-death processes with disease status under intermittent observation
Moon, Nathalie C.; Zeng, Leilei; Cook, Richard J. (Taylor & Francis, 2019-12-12)Cohort studies are routinely conducted to learn about the incidence or progression rates of chronic diseases. The illness-death model offers a natural framework for joint consideration of non-fatal events in the semi-competing ... -
Composite likelihood for aggregate data from clustered multistate processes under intermittent observation
Jiang, Shu; Cook, Richard J. (Taylor & Francis, 2019-03-11)Markov processes offer a useful basis for modeling the progression of organisms through successive stages of their life cycle. When organisms are examined intermittently in developmental studies, likelihoods can be constructed ... -
Composite likelihood for joint analysis of multiple multistate processes via copulas
Cook, Richard J.; Diao, Liqun (Oxford Journals, 2014-10)A copula-based model is described which enables joint analysis of multiple progressive multistate processes. Unlike intensity-based or frailty-based approaches to joint modeling, the copula formulation proposed herein ... -
A copula model for marked point processes
Diao, Liqun; Cook, Richard J.; Lee, Ker-Ai (Springer, 2013)Many chronic diseases feature recurring clinically important events. In addition, however, there often exists a random variable which is realized upon the occurrence of each event reflecting the severity of the event, a ... -
A Cox-Aalen model for interval-censored data
Cook, Richard J.; Boruvka, Audrey (Wiley, 2015-06)The Cox-Aalen model, obtained by replacing the baseline hazard function in the well-known Cox model with a covariate-dependent Aalen model, allows for both fixed and dynamic covariate effects. In this paper, we examine ... -
Dependence modeling for multi-type recurrent events via copulas
Lee, Jooyoung; Cook, Richard J. (Wiley, 2019-09-20)When several types of recurrent events may arise, interest often lies in marginal modeling and studying the nature of the dependence structure. In this paper, we propose a multivariate mixed-Poisson model with the dependence ... -
Design of cancer trials based on progression-free survival with intermittent assessment
Zeng, Leilei; Cook, Richard J.; Lee, Ker-Ai (Wiley, 2018-03-26)Therapeutic advances in cancer mean that it is now impractical to performed phase III randomized trials evaluating experimental treatments on the basis of overall survival. As a result, the composite endpoint of progression-free ... -
The Design of Intervention Trials Involving Recurrent and Terminal Events
Wu, Longyang; Cook, Richard J. (Springer, 2013)Clinical trials are often designed to assess the effect of therapeutic interventions on the incidence of recurrent events in the presence of a dependent terminal event such as death. Statistical methods based on multistate ... -
Does Cox analysis of a randomized survival study yield a causal treatment effect?
Cook, Richard J.; Aalen, Odd O.; Røysland, Kjetil (Springer US, 2015-10)Statistical methods for survival analysis play a central role in the assessment of treatment effects in randomized clinical trials in cardiovascular disease, cancer, and many other fields. The most common approach to ... -
A dynamic Mover–Stayer model for recurrent event processes subject to resolution
Cook, Richard J.; Shen, Hua (Springer US, 2014-07)In studies of affective disorder, individuals are often observed to experience recurrent symptomatic exacerbations warranting hospitalization. Interest may lie in modeling the occurrence of such exacerbations over time ... -
The effect of omitted covariates in marginal and partially conditional recurrent event analyses
Zhong, Yujie; Cook, Richard J. (Springer, 2019-04-01)There have been many advances in statistical methodology for the analysis of recurrent event data in recent years. Multiplicative semiparametric rate-based models are widely used in clinical trials, as are more general ... -
Failure time studies with intermittent observation and losses to follow-up
Cook, Richard J.; Lawless, Jerald F. (Wiley, 2020-12-01)In health research interest often lies in modeling a failure time process but in many cohort studies failure status is only determined at scheduled assessment times. While the assessment times may be fixed upon study entry, ... -
Identifying patterns of alcohol use among secondary school students in Canada: A multilevel latent class analysis
Gohari, Mahmood R.; Cook, Richard J.; Dubin, Joel A.; Leatherdale, Scott T. (Elsevier, 2020-01)Harm from alcohol use depend not only on the volume of consumption but also on drinking patterns. This study identifies patterns of alcohol consumption in youth and investigates how these patterns vary across schools and ... -
The illness-death model for family studies
Lee, Jooyoung; Cook, Richard (Oxford University Press, 2021-07)Family studies involve the selection of affected individuals from a disease registry who provide right-truncated ages of disease onset. Coarsened disease histories are then obtained from consenting family members, either ... -
Independence conditions and the analysis of life history studies with intermittent observation
Cook, Richard; Lawless, Jerald (Oxford University Press, 2021-07)Multistate models provide a powerful framework for the analysis of life history processes when the goal is to characterize transition intensities, transition probabilities, state occupancy probabilities, and covariate ... -
Inverse Probability Weighted Estimating Equations for Randomized Trials in Transfusion Medicine
Cook, Richard J.; Lee, Ker-Ai; Cuerden, Meaghan; Cotton, Cecilia (Wiley, 2013-03-26)Thrombocytopenia is a condition characterized by extremely low platelet counts, which puts patients at elevated risk of morbidity and mortality because of bleeding. Trials in transfusion medicine are routinely designed ...