Browsing University of Waterloo by Author "Desoky, Ahmed"
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Structural and Kinetic Studies on the Potent Inhibition of Metallo-β-Lactamases by 6- Phosphonomethylpyridine-2-Carboxylates
HInchliffe, Philip; Tanner, Carol A.; Krismanich, Anthony; Labbé, Geneviève; Goodfellow, Valerie J.; Marrone, Laura; Desoky, Ahmed; Calvopiña, Karina; Whittle, Emily E.; Zeng, Fanxing; Avison, Mathew B.; Bols, Niels C.; Siemann, Stefan; Spencer, James; Dmitrienko, Gary I. (American Chemical Society, 2018-02-27)There are currently no clinically available inhibitors of metallo-β-lactamases (MBLs), enzymes which hydrolyze β-lactam antibiotics and confer resistance on Gram-negative bacteria. Here we present 6-phosphonomethylpyridi ... -
Synthesis of Sulfated Carbohydrates Using Sulfuryl Imidazolium Salts
Desoky, Ahmed (University of Waterloo, 2010-11-24)Sulfated polysaccharides are widespread in nature. These compounds are implicated in a wide variety of important biological processes such as blood clotting, cell adhesion, and cell–cell communication. However, detailed ...